Development of Tissue Adhesives Based on Amphiphilic Isocyanate-Terminated Trimethylene Carbonate Block Copolymers

被引：23

作者：

Bochynska, Agnieszka I. ^{[1
,3
]}

Sharifi, Shahriar ^{[2
]}

van Tienen, Tony G. ^{[3
]}

Buma, Pieter ^{[3
]}

Grijpma, Dirk W. ^{[1
,2
]}

机构：

[1] Univ Twente, Dept Biomat Sci & Technol, NL-7500 AE Enschede, Netherlands

[2] Univ Groningen, Dept Biomed Engn, Univ Med Ctr Groningen, Groningen, Netherlands

[3] Radboud Univ Nijmegen, Med Ctr, Dept Orthopaed, Orthopaed Res Lab,Nijmegen Ctr Mol Life Sci, NL-6525 ED Nijmegen, Netherlands

来源：

MACROMOLECULAR SYMPOSIA | 2013年 / 334卷 / 01期

关键词：

biodegradable; poly(trimethylene carbonate) isocyanate functionalization; star polymer; tissue adhesive; SEALANTS;

D O I：

10.1002/masy.201300101

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

In this study, novel 3-armed star-shaped isocyanate-terminated block copolymers based on trimethylolpropane ethoxylate (TMPE) and trimethylene carbonate (TMC) varying in composition were designed and synthesized. By reaction with water, networks were formed. The characteristics of these networks were compared with those prepared from analogous linear structures based on polyethylene glycol (PEG) and TMC. Tensile testing of the networks highlighted good mechanical properties. In lap shear adhesion tests to chamois leather, very good bonding strengths of up to 0.6 MPa were obtained. These values compare favorably with those of Dermabond (R), which is currently one of the strongest clinically used tissue adhesives.

引用

页码：40 / 48

页数：9

共 16 条

[11] Elasticity and safety of alkoxyethyl cyanoacrylate tissue adhesives [J].