Malignant insulinoma: Recommendations for workup and treatment

被引：9

作者：

Baudin, Eric ^{[1
]}

Caron, Philippe ^{[2
]}

Lombard-Bohas, Catherine ^{[3
]}

Tabarin, Antoine ^{[4
]}

Mitry, Emmanuel ^{[5
]}

Reznick, Yves ^{[6
]}

Taieb, David ^{[7
]}

Pattou, Francois ^{[8
]}

Goudet, Pierre ^{[9
]}

Vezzosi, Delphine ^{[2
]}

Scoazec, Jean-Yves ^{[10
]}

Cadiot, Guillaume ^{[11
]}

Borson-Chazot, Francoise ^{[12
,13
]}

Do Cao, Christine ^{[14
]}

机构：

[1] Inst Gustave Roussy, Serv Med Nucl & Oncol Endocrinienne, F-94805 Villejuif, France

[2] CHU Rangueil Larrey, Serv Endocrinol & Malad Metab, F-31059 Toulouse 9, France

[3] Hop Edouard Herriot, F-69003 Lyon, France

[4] Hop Haut Leveque, Serv Endocrinol, F-33600 Pessac, France

[5] Hop Rene Huguenin, Inst Curie, Serv Oncogastroenterol, F-92210 St Cloud, France

[6] CHU Cote Nacre, Unite Fonct Endocrinol & Malad Metab, F-14033 Caen, France

[7] CHU Timone, Serv Cent Biophys & Med Nucl, F-13005 Marseille, France

[8] Hop Claude Huriez, Serv Chirurg Endocrinienne, F-59000 Lille, France

[9] CHU Dijon, Serv Chirurg Gen & Endocrinienne, F-21000 Dijon, France

[10] Inst Gustave Roussy, Serv Biol & Pathol Med, F-94805 Villejuif, France

[11] Hop Robert Debre, Serv Hepatogastroenterol & Cancerol Digest, F-51100 Reims, France

[12] Hosp Civils Lyon, F-69500 Lyon, France

[13] Ctr Med Nucl, F-69500 Lyon, France

[14] Hop Claude Huriez, Serv Endocrinol & Malad Metab, F-59000 Lille, France

来源：

PRESSE MEDICALE | 2014年 / 43卷 / 06期

关键词：

RECEPTOR RADIONUCLIDE THERAPY; ENETS CONSENSUS GUIDELINES; NEUROENDOCRINE GASTROENTEROPANCREATIC TUMORS; PANCREATIC ENDOCRINE TUMORS; LIVER METASTASES; SOMATOSTATIN ANALOG; PROGNOSTIC-FACTORS; SEVERE HYPOGLYCEMIA; LOW-GRADE; INTRACTABLE HYPOGLYCEMIA;

D O I：

10.1016/j.lpm.2013.08.007

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Insulinoma are malignant in 4 to 14 % of cases. Their rarity and the sparse data available in the literature have limited publication of specific guidelines for their management. The following review aim to provide up-to-date recommendations on initial evaluation including pathologic grading, measures to control hypoglycemia, antitumor strategies and long term follow-up. Will be discussed in detail respective indications of surgery, diazoxide, somatostatin analogs, everolimus, sunitinib, liver directed treatments including arterial embolizotion, chemotherapy and radiometabolic therapy. A Medline search using terms "insulinoma", "neuroendocrine pancreatic tumors", "islet cell carcinoma", "malignant insulinoma" was performed limiting the selection to English language articles and adult age cases, along with cross referencing.

引用

页码：645 / 659

页数：15

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