A new phenylpropanoid and an alkylglycoside from Piper retrofractum leaves with their antioxidant and α-glucosidase inhibitory activity

被引：33

作者：

Bui Thi Thuy Luyen ^{[1
]}

Bui Huu Tai ^{[1
,2
]}

Nguyen Phuong Thao ^{[1
,2
]}

Yang, Seo Young ^{[1
]}

Nguyen Manh Cuong ^{[3
]}

Kwon, Young In ^{[4
]}

Jang, Hae Dong ^{[4
]}

Kim, Young Ho ^{[1
]}

机构：

[1] Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea

[2] Vietnam Acad Sci & Technol, Inst Marine Biochem IMBC, Hanoi, Vietnam

[3] Vietnam Acad Sci & Technol, Inst Nat Prod Chem, Hanoi, Vietnam

[4] Hannam Univ, Dept Food & Nutr, Taejon 305811, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2014年 / 24卷 / 17期

基金：

新加坡国家研究基金会;

关键词：

Piper retrofractum; Piperoside; Isoheptanol 2(S)-O-beta-D-xylopyranosyl (1 -> 6)-O-beta-D-glucopyranoside; Antioxidant; alpha-Glucosidase inhibitor; GLYCOSIDES; CONSTITUENTS; OBESITY;

D O I：

10.1016/j.bmcl.2014.07.057

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new compounds, piperoside (1) and isoheptanol 2(S)-O-beta-D-xylopyranosyl (1 -> 6)-O-beta-D-glucopyranoside (11), along with 10 known compounds 3,4-dihydroxyallylbenzene (2), 1,2-di-O-beta-D-glucopyranosy14-allylbenzene (3), tachioside (4), benzyl-O-beta-D-glucopyranoside (5), icariside F2(6), dihydrovomifolio1-3'-O-beta-D-glucopyranoside (7), isopropyl 0-6-o-glucopyranoside (8), isopropyl primeveroside (9), n-butyl O-beta-D-glucopyranoside (10), isoheptanol 2(S)-O-beta-D-apiofuranosyl-(1 -> 6)-O-beta-D-glucopyranoside (12), were isolated from the leaves of Piper retrofractum. Their structures were determined from 1D-NMR, 2D-NMR, and HR-ESI-MS spectral, a modified Masher's method, and comparisons with previous reports. All of the isolated compounds showed modest oc-glucosidase inhibitory (4.60 1.74% to 11.97 3.30%) and antioxidant activities under the tested conditions. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：4120 / 4124

页数：5

共 25 条

[21] New Pyrano-Pyrone from Goniothalamus tamirensis Enhances the Proliferation and Differentiation of Osteoblastic MC3T3-E1 Cells [J].