Effect of alpha lipoic acid on ifosfamide-induced central neurotoxicity in rats

被引：6
作者：
Ozturk, Gulfer [1 ,2 ]
Ginis, Zeynep [1 ,2 ]
Kurt, Sefika Nur [3 ]
Albayrak, Aynur [4 ]
Bilen, Sule [5 ]
Fadillioglu, Ersin [2 ,3 ]
机构：
[1] Ankara Diskapi Yildirim Beyazit Educ & Res Hosp, Dept Clin Biochem, TR-06010 Ankara, Turkey
[2] Pancreas Islet Res Ctr, Ankara, Turkey
[3] Hacettepe Univ, Fac Med, Dept Physiol, TR-06100 Ankara, Turkey
[4] Ankara Diskapi Yildirim Beyazit Educ & Res Hosp, Dept Pathol, TR-06010 Ankara, Turkey
[5] Ankara Numune Training & Res Hosp, Dept Neurol, Ankara, Turkey
来源：
INTERNATIONAL JOURNAL OF NEUROSCIENCE | 2014年 / 124卷 / 02期
关键词：
caspase; 3; antioxidant; brain; ifosfamide; alpha lipoic acid; LIPID-PEROXIDATION; OXIDATIVE STRESS; PHENETHYL ESTER; TOXICITY; ENCEPHALOPATHY; ANTIOXIDANTS; PRETREATMENT; METABOLISM; CHILDHOOD; PROTECTS;
D O I：
10.3109/00207454.2013.823962
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Ifosfamide (IFOS) which is a cytotoxic alkylating agent may cause central nervous system toxicity. Alpha-lipoic acid (ALA) has a strong antioxidant effects. We hypothesized that ALA could attenuate on ifosfamide-induced central neurotoxicity in rats. Rats were divided into Control, IFOS, ALA and IFOS+ALA groups. The toxic effects of IFOS were analyzed by oxidative parameters and caspase 3 immunohistochemical examinations of brain tissue. The catalase activity of IFOS group significantly reduced in comparison with control groups (p < 0.05). The malondialdehyde (MDA) level and protein carbonyl (PC) content in brain tissue were significantly higher in IFOS group than in the other groups (p < 0.05). ALA treatments significantly prevented the increase in MDA level (p < 0.001) and PC content (p < 0.05) in brain tissue. IFOS group showed profound activation of caspase 3. The control, ALA and IFOS+ALA groups did not show caspase 3 activation. It was concluded that ALA treatments may have beneficial effects protecting neurons from central neurotoxicity caused by IFOS.
引用
收藏
页码：110 / 116
页数：7
相关论文
共 43 条
[1]   α-lipoic acid prevents 3,4-methylenedioxymethamphetamine (MDMA)-induced neurotoxicity [J].
Aguirre, N ;
Barrionuevo, M ;
Ramírez, MJ ;
Del Río, J ;
Lasheras, B .
NEUROREPORT, 1999, 10 (17) :3675-3680
[2]   Ifosfamide encephalopathy [J].
Ajithkumar, T. ;
Parkinson, C. ;
Shamshad, F. ;
Murray, P. .
CLINICAL ONCOLOGY, 2007, 19 (02) :108-114
[3]   The indices of endogenous oxidative and antioxidative processes in plasma from schizophrenic patients The possible role of oxidant/antioxidant imbalance [J].
Akyol, Ö ;
Herken, H ;
Uz, E ;
Fadillioglu, E ;
Ünal, S ;
Sögüt, S ;
Özyurt, H ;
Savas, HA .
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2002, 26 (05) :995-1005
[4]  
[Anonymous], 1974, Catalase. Methods Enzym. Anal., DOI DOI 10.1016/B978-0-12-091302-2.50032-3
[5]   Chronic Pretreatment with Acetyl-L-Carnitine and ±DL-α-Lipoic Acid Protects Against Acute Glutamate-Induced Neurotoxicity in Rat Brain by Altering Mitochondrial Function [J].
Babu, G. Nagesh ;
Kumar, Alok ;
Singh, Ram Lakhan .
NEUROTOXICITY RESEARCH, 2011, 19 (02) :319-329
[6]   The pharmacology of the antioxidant lipoic acid [J].
Biewenga, GP ;
Haenen, GRMM ;
Bast, A .
GENERAL PHARMACOLOGY, 1997, 29 (03) :315-331
[7]  
Bilska A, 2005, PHARMACOL REP, V57, P570
[8]   α-LIPOIC ACID AS A POTENTIAL TARGET FOR THE TREATMENT OF LUNG INJURY CAUSED BY CECAL LIGATION AND PUNCTURE-INDUCED SEPSIS MODEL IN RATS [J].
Cadirci, Elif ;
Altunkaynak, Berrin Zuhal ;
Halici, Zekai ;
Odabasoglu, Fehmi ;
Uyanik, M. Hamidullah ;
Gundogdu, Cemal ;
Suleyman, Halis ;
Halici, Mesut ;
Albayrak, Mevlut ;
Unal, Bunyami .
SHOCK, 2010, 33 (05) :479-484
[9]   Effect of α-lipoic acid on lipid peroxidation and anti-oxidant enzyme activities in diabetic rats [J].
Dinçer, Y ;
Telci, A ;
Kayali, R ;
Yilmaz, IA ;
Çakatay, U ;
Akçay, T .
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2002, 29 (04) :281-284
[10]   Lipoic acid inhibits caspase-dependent and -independent cell death pathways and is neuroprotective against hippocampal damage after pilocarpine-induced seizures [J].
dos Santos, Pauline Sousa ;
Feitosa, Chistiane Mendes ;
Saldanha, Glaucio Barros ;
Tome, Adriana da Rocha ;
Feng, Dejiang ;
de Freitas, Rivelilson Mendes .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2011, 97 (03) :531-536
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