Phenytoin-induced cerebellar atrophy in an epileptic boy

被引：6

作者：

Kumar, Nithin ^{[1
]}

Chakraborty, Ananya ^{[2
]}

Suresh, Swaroop H. ^{[2
]}

Basappaji, Sashidharan ^{[3
]}

Betdur, Anand L. ^{[3
]}

机构：

[1] Vydehi Inst Med Sci & Res Ctr, Dept Neurol, Bangalore, Karnataka, India

[2] Vydehi Inst Med Sci & Res Ctr, Dept Pharmacol, Bangalore, Karnataka, India

[3] Vydehi Inst Med Sci & Res Ctr, Dept Med, Bangalore, Karnataka, India

来源：

INDIAN JOURNAL OF PHARMACOLOGY | 2013年 / 45卷 / 06期

关键词：

Adverse drug reaction; antiepileptic drugs; antiseizure drugs; cerebellar atrophy; phenytoin; DEGENERATION; THERAPY;

D O I：

10.4103/0253-7613.121388

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Epilepsy is an important health problem due to its high prevalence and potential for causing long-term morbidity. It is commonly treated in children with phenytoin sodium. It has wide pharmacokinetic variability and a narrow therapeutic range that leads to toxicity. Here, we report a case of phenytoin-induced cerebellar atrophy in a 16-year-old epileptic boy who presented to the hospital with a viral infection.

引用

页码：636 / 637

页数：2

共 7 条

[1]

Ahuja S R, 2000, J Postgrad Med, V46, P278

[2] Phenytoin induced chorea in a pediatric patient: An interaction between phenytoin, phenobarbital and clobazam [J].

Barvaliya, Manish ;

Sanmukhani, Jayesh ;

Patel, Tejas K. ;

Tripathi, C. B. .

INDIAN JOURNAL OF PHARMACOLOGY, 2011, 43 (06) :731-732

[3] CEREBELLAR DEGENERATION FOLLOWING LONG-TERM PHENYTOIN THERAPY [J].

GHATAK, NR ;

SANTOSO, RA ;

MCKINNEY, WM .

NEUROLOGY, 1976, 26 (09) :818-820

[4]

Kshirsagar N A, 1996, Indian Pediatr, V33, P993

[5] Cerebellar atrophy after acute phenytoin intoxication [J].

Kuruvilla, T ;

Bharucha, NE .

EPILEPSIA, 1997, 38 (04) :500-502

[6]

Longo DH., 2012, HARRISONS PRINCIPLES

[7]

MCLAIN LW, 1980, ANN NEUROL, V7, P18

← 1 →