Bioactive Lactones from the Mangrove-Derived Fungus Penicillium sp. TGM112

被引：30
|
作者：
Bai, Meng [1 ,2 ]
Huang, Guo-Lei [1 ,2 ]
Mei, Rong-Qing [1 ,2 ]
Wang, Bin [1 ,2 ]
Luo, You-Ping [1 ,2 ]
Nong, Xu-Hua [1 ,2 ]
Chen, Guang-Ying [1 ,2 ]
Zheng, Cai-Juan [1 ,2 ]
机构：
[1] Hainan Normal Univ, Coll Chem & Chem Engn, Minist Educ, Key Lab Trop Med Resource Chem, Haikou 571158, Hainan, Peoples R China
[2] Hainan Normal Univ, Key Lab Trop Med Plant Chem Hainan Prov, Haikou 571158, Hainan, Peoples R China
来源：
MARINE DRUGS | 2019年 / 17卷 / 08期
基金：
中国国家自然科学基金;
关键词：
Penicillium sp; lactones; antibacterial activity; insecticidal activity; ABSOLUTE-CONFIGURATION; DERIVATIVES;
D O I：
10.3390/md17080433
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Three new lactones penicilactones A-C (1-3) were obtained from the mangrove-derived fungus Penicillium sp. TGM112. Their structures and absolute configurations were determined by detailed NMR, MS spectroscopic data, Mo-2(OAc)(4)-induced electronic circular dichroism (ECD), and circular dichroism (CD) spectroscopy. Compound 1 showed antibacterial activity against Staphylococcus aureus with an MIC value of 6.25 mu g/mL. Compound 2 showed insecticidal activity against newly hatched larvae of Culex quinquefasciatus with the LC50 value of 78.5 (+/- 0.58) mu g/mL.
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页数：7
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