Bioactive Lactones from the Mangrove-Derived Fungus Penicillium sp. TGM112

被引：30

作者：

Bai, Meng ^{[1
,2
]}

Huang, Guo-Lei ^{[1
,2
]}

Mei, Rong-Qing ^{[1
,2
]}

Wang, Bin ^{[1
,2
]}

Luo, You-Ping ^{[1
,2
]}

Nong, Xu-Hua ^{[1
,2
]}

Chen, Guang-Ying ^{[1
,2
]}

Zheng, Cai-Juan ^{[1
,2
]}

机构：

[1] Hainan Normal Univ, Coll Chem & Chem Engn, Minist Educ, Key Lab Trop Med Resource Chem, Haikou 571158, Hainan, Peoples R China

[2] Hainan Normal Univ, Key Lab Trop Med Plant Chem Hainan Prov, Haikou 571158, Hainan, Peoples R China

来源：

MARINE DRUGS | 2019年 / 17卷 / 08期

基金：

中国国家自然科学基金;

关键词：

Penicillium sp; lactones; antibacterial activity; insecticidal activity; ABSOLUTE-CONFIGURATION; DERIVATIVES;

D O I：

10.3390/md17080433

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Three new lactones penicilactones A-C (1-3) were obtained from the mangrove-derived fungus Penicillium sp. TGM112. Their structures and absolute configurations were determined by detailed NMR, MS spectroscopic data, Mo-2(OAc)(4)-induced electronic circular dichroism (ECD), and circular dichroism (CD) spectroscopy. Compound 1 showed antibacterial activity against Staphylococcus aureus with an MIC value of 6.25 mu g/mL. Compound 2 showed insecticidal activity against newly hatched larvae of Culex quinquefasciatus with the LC50 value of 78.5 (+/- 0.58) mu g/mL.

引用

页数：7

共 50 条

[1] Bioactive Austin Meroterpenes from the Mangrove-Derived Fungus Penicillium sp. TGM112
Zeng, Wei-Nv
Chen, Shi-Ji
Wang, Bin
Huang, Guo-Lei
Sun, Zhen-Fan
Zheng, Cai-Juan
CHEMISTRY OF NATURAL COMPOUNDS, 2024, 60 (06) : 1139 - 1142
[2] A new bioactive isocoumarin from the mangrove-derived fungus Penicillium sp. TGM112
Zeng, Wei-Nv
Cai, Jin
Wang, Bin
Chen, Liang-Yu
Pan, Chen-Xin
Chen, Shi-Ji
Huang, Guo-Lei
Zheng, Cai-Juan
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2022, 24 (07) : 679 - 684
[3] Secondary Metabolites from the Mangrove-Derived Fungus Penicillium sp. TGM112 and their Bioactivities
Wei-Nv Zeng
Bin Jin-Cai
Liang-Yu Wang
Chen-Xin Chen
Shi-Ji Pan
Guo-Lei Chen
Cai-Juan Huang
Chemistry of Natural Compounds, 2022, 58 : 574 - 577
[4] SECONDARY METABOLITES FROM THE MANGROVE-DERIVED FUNGUS Penicillium sp. TGM112 AND THEIR BIOACTIVITIES
Zeng, Wei-Nv
Jin-Cai
Wang, Bin
Chen, Liang-Yu
Pan, Chen-Xin
Chen, Shi-Ji
Huang, Guo-Lei
Zheng, Cai-Juan
CHEMISTRY OF NATURAL COMPOUNDS, 2022, 58 (03) : 574 - 577
[5] Bioactive Meroterpenoids and Isocoumarins from the Mangrove Derived Fungus Penicillium sp. TGM112
Bai, Meng
Zheng, Cai-Juan
Huang, Guo-Lei
Mei, Rong-Qing
Wang, Bin
Luo, You-Ping
Zheng, Chao
Niu, Zhi-Gang
Chen, Guang-Ying
JOURNAL OF NATURAL PRODUCTS, 2019, 82 (05): : 1155 - 1164
[6] New Bioactive Polyketides from the Mangrove-Derived Fungus Penicillium sp. SCSIO 41411
Chen, Yi
Cai, Jian
Xia, Ziwei
Chen, Chunmei
Liu, Yonghong
Jayasinghe, Lalith
Wang, Xueni
Zhou, Xuefeng
MARINE DRUGS, 2024, 22 (09)
[7] Bioactive isocoumarins isolated from a mangrove-derived fungus Penicillium sp. MGP11
Mei, Rong-Qing
Wang, Bin
Zeng, Wei-Nv
Huang, Guo-Lei
Chen, Guang-Ying
Zheng, Cai-Juan
NATURAL PRODUCT RESEARCH, 2022, 36 (05) : 1260 - 1265
[8] Study on Bioactive Secondary Metabolites from the Mangrove-Derived Fungus Penicillium verruculosum TGM14
Wang, Bin
Nong, Xu-Hua
Zeng, Wei-Nv
Li, Shan-Shan
Li, Gao-Yu
Liu, Jing
Huang, Guo-Lei
Zheng, Cai-Juan
CHEMISTRY OF NATURAL COMPOUNDS, 2022, 58 (05) : 812 - 815
[9] Study on Bioactive Secondary Metabolites from the Mangrove-Derived Fungus Penicillium verruculosum TGM14
Bin Wang
Xu-Hua Nong
Wei-Nv Zeng
Shan-Shan Li
Gao-Yu Li
Jing Liu
Guo-Lei Huang
Cai-Juan Zheng
Chemistry of Natural Compounds, 2022, 58 : 812 - 815
[10] Two new benzophenones isolated from a mangrove-derived fungus Penicillium sp.
Bai, Meng
Gao, Cheng-Hai
Liu, Kai
Zhao, Long-Yan
Tang, Zhen-Zhou
Liu, Yong-Hong
JOURNAL OF ANTIBIOTICS, 2021, 74 (11): : 821 - 824

← 1 2 3 4 5 →