Bioactive Lactones from the Mangrove-Derived Fungus Penicillium sp. TGM112

被引：31

作者：

Bai, Meng ^{[1
,2
]}

Huang, Guo-Lei ^{[1
,2
]}

Mei, Rong-Qing ^{[1
,2
]}

Wang, Bin ^{[1
,2
]}

Luo, You-Ping ^{[1
,2
]}

Nong, Xu-Hua ^{[1
,2
]}

Chen, Guang-Ying ^{[1
,2
]}

Zheng, Cai-Juan ^{[1
,2
]}

机构：

[1] Hainan Normal Univ, Coll Chem & Chem Engn, Minist Educ, Key Lab Trop Med Resource Chem, Haikou 571158, Hainan, Peoples R China

[2] Hainan Normal Univ, Key Lab Trop Med Plant Chem Hainan Prov, Haikou 571158, Hainan, Peoples R China

来源：

MARINE DRUGS | 2019年 / 17卷 / 08期

基金：

中国国家自然科学基金;

关键词：

Penicillium sp; lactones; antibacterial activity; insecticidal activity; ABSOLUTE-CONFIGURATION; DERIVATIVES;

D O I：

10.3390/md17080433

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Three new lactones penicilactones A-C (1-3) were obtained from the mangrove-derived fungus Penicillium sp. TGM112. Their structures and absolute configurations were determined by detailed NMR, MS spectroscopic data, Mo-2(OAc)(4)-induced electronic circular dichroism (ECD), and circular dichroism (CD) spectroscopy. Compound 1 showed antibacterial activity against Staphylococcus aureus with an MIC value of 6.25 mu g/mL. Compound 2 showed insecticidal activity against newly hatched larvae of Culex quinquefasciatus with the LC50 value of 78.5 (+/- 0.58) mu g/mL.

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