Imputation of orofacial clefting data identifies novel risk loci and sheds light on the genetic background of cleft lip 6 cleft palate and cleft palate only

被引：83

作者：

Ludwig, Kerstin U. ^{[1
,2
]}

Boehmer, Anne C. ^{[1
,2
]}

Bowes, John ^{[3
]}

Nikolic, Milos ^{[4
,5
]}

Ishorst, Nina ^{[1
,2
]}

Wyatt, Niki ^{[6
]}

Hammond, Nigel L. ^{[6
]}

Goelz, Lina ^{[7
]}

Thieme, Frederic ^{[1
,2
]}

Barth, Sandra ^{[1
,2
]}

Schuenke, Hannah ^{[1
,2
]}

Klamt, Johanna ^{[1
,2
]}

Spielmann, Malte ^{[8
,9
,10
]}

Aldhorae, Khalid ^{[11
]}

Rojas-Martinez, Augusto ^{[12
,13
]}

Noethen, Markus M. ^{[1
,2
]}

Rada-Iglesias, Alvaro ^{[4
,5
]}

Dixon, Michael J. ^{[6
]}

Knapp, Michael ^{[14
]}

Mangold, Elisabeth ^{[1
]}

机构：

[1] Univ Bonn, Inst Human Genet, D-53127 Bonn, Germany

[2] Univ Bonn, Life & Brain Ctr, Dept Genom, D-53127 Bonn, Germany

[3] Univ Manchester, Arthritis Res UK Ctr Genet & Genom, Manchester M13 9PT, Lancs, England

[4] Univ Cologne, Ctr Mol Med Cologne, D-50931 Cologne, Germany

[5] Univ Cologne, Cologne Excellence Cluster Cellular Stress Respon, D-50931 Cologne, Germany

[6] Univ Manchester, Fac Biol Med & Hlth, Manchester M13 9PT, Lancs, England

[7] Univ Bonn, Dept Orthodont, D-53111 Bonn, Germany

[8] Max Planck Inst Mol Genet, RG Dev & Dis, D-14195 Berlin, Germany

[9] Charite, Inst Med & Human Genet, D-13353 Berlin, Germany

[10] Charite, BCRT, D-13353 Berlin, Germany

[11] Thamar Univ, Coll Dent, Dept Orthodont, Thamar, Yemen

[12] Sch Med, Tecnol Monterrey, Monterrey 64460, Mexico

[13] Univ Autonoma Nuevo Leon, Ctr Invest Desarrollo Ciencias Salud, Monterrey 64460, Mexico

[14] Univ Bonn, Inst Med Biometry Informat & Epidemiol, D-53127 Bonn, Germany

来源：

HUMAN MOLECULAR GENETICS | 2017年 / 26卷 / 04期

关键词：

GENOME-WIDE ASSOCIATION; SUSCEPTIBILITY LOCI; THYROID-CANCER; ORAL CLEFTS; VARIANTS; GWAS; ENHANCERS; METAANALYSIS; DISRUPTION; MUTATIONS;

D O I：

10.1093/hmg/ddx012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nonsyndromic cleft lip with or without cleft palate (nsCL/P) is among the most common human birth defects with multifactorial etiology. Here, we present results from a genome-wide imputation study of nsCL/P in which, after adding replication cohort data, four novel risk loci for nsCL/P are identified ( at chromosomal regions 2p21, 14q22, 15q24 and 19p13). On a systematic level, we show that the association signals within this high-density dataset are enriched in functionally-relevant genomic regions that are active in both human neural crest cells (hNCC) and mouse embryonic craniofacial tissue.

引用

页码：829 / 842

页数：14

共 72 条

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Adhikari, Kaustubh ;

Fuentes-Guajardo, Macarena ;

Quinto-Sanchez, Mirsha ;

Mendoza-Revilla, Javier ;

Chacon-Duque, Juan Camilo ;

Acuna-Alonzo, Victor ;

Jaramillo, Claudia ;

Arias, William ;

Barquera Lozano, Rodrigo ;

Macin Perez, Gaston ;

Gomez-Valdes, Jorge ;

Villamil-Ramirez, Hugo ;

Hunemeier, Tabita ;

Ramallo, Virginia ;

Silva de Cerqueira, Caio C. ;

Hurtado, Malena ;

Villegas, Valeria ;

Granja, Vanessa ;

Gallo, Carla ;

Poletti, Giovanni ;

Schuler-Faccini, Lavinia ;

Salzano, Francisco M. ;

Bortolini, Maria-Catira ;

Canizales-Quinteros, Samuel ;

Cheeseman, Michael ;

Rosique, Javier ;

Bedoya, Gabriel ;

Rothhammer, Francisco ;

Headon, Denis ;

Gonzalez-Jose, Rolando ;

Balding, David ;

Ruiz-Linares, Andres .

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[2] A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer [J].

Al-Tassan, Nada A. ;

Whiffin, Nicola ;

Hosking, Fay J. ;

Palles, Claire ;

Farrington, Susan M. ;

Dobbins, Sara E. ;

Harris, Rebecca ;

Gorman, Maggie ;

Tenesa, Albert ;

Meyer, Brian F. ;

Wakil, Salma M. ;

Kinnersley, Ben ;

Campbell, Harry ;

Martin, Lynn ;

Smith, Christopher G. ;

Idziaszczyk, Shelley ;

Barclay, Ella ;

Maughan, Timothy S. ;

Kaplan, Richard ;

Kerr, Rachel ;

Kerr, David ;

Buchannan, Daniel D. ;

Win, Aung Ko ;

Hopper, John ;

Jenkins, Mark ;

Lindor, Noralane M. ;

Newcomb, Polly A. ;

Gallinger, Steve ;

Conti, David ;

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Cheadle, Jeremy P. ;

Houlston, Richard S. .

SCIENTIFIC REPORTS, 2015, 5

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Aldhorae, Khalid Ahmed ;

Boehmer, Anne C. ;

Ludwig, Kerstin U. ;

Esmail, Ahlam Hibatulla Ali ;

Al-Hebshi, Nezar Noor ;

Lippke, Baerbel ;

Goelz, Lina ;

Noethen, Markus M. ;

Daratsianos, Nikolaos ;

Knapp, Michael ;

Jaeger, Andreas ;

Mangold, Elisabeth .

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Altshuler, David M. ;

Durbin, Richard M. ;

Abecasis, Goncalo R. ;

Bentley, David R. ;

Chakravarti, Aravinda ;

Clark, Andrew G. ;

Donnelly, Peter ;

Eichler, Evan E. ;

Flicek, Paul ;

Gabriel, Stacey B. ;

Gibbs, Richard A. ;

Green, Eric D. ;

Hurles, Matthew E. ;

Knoppers, Bartha M. ;

Korbel, Jan O. ;

Lander, Eric S. ;

Lee, Charles ;

Lehrach, Hans ;

Mardis, Elaine R. ;

Marth, Gabor T. ;

McVean, Gil A. ;

Nickerson, Deborah A. ;

Wang, Jun ;

Wilson, Richard K. ;

Boerwinkle, Eric ;

Doddapaneni, Harsha ;

Han, Yi ;

Korchina, Viktoriya ;

Kovar, Christie ;

Lee, Sandra ;

Muzny, Donna ;

Reid, Jeffrey G. ;

Zhu, Yiming ;

Chang, Yuqi ;

Feng, Qiang ;

Fang, Xiaodong ;

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Jiang, Hui ;

Jin, Xin ;

Lan, Tianming ;

Li, Guoqing ;

Li, Jingxiang ;

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Attanasio, Catia ;

Nord, Alex S. ;

Zhu, Yiwen ;

Blow, Matthew J. ;

Li, Zirong ;

Liberton, Denise K. ;

Morrison, Harris ;

Plajzer-Frick, Ingrid ;

Holt, Amy ;

Hosseini, Roya ;

Phouanenavong, Sengthavy ;

Akiyama, Jennifer A. ;

Shoukry, Malak ;

Afzal, Veena ;

Rubin, Edward M. ;

FitzPatrick, David R. ;

Ren, Bing ;

Hallgrimsson, Benedikt ;

Pennacchio, Len A. ;

Visel, Axel .

SCIENCE, 2013, 342 (6157)

[6] Confirming genes influencing risk to cleft lip with/without cleft palate in a case-parent trio study [J].

Beaty, T. H. ;

Taub, M. A. ;

Scott, A. F. ;

Murray, J. C. ;

Marazita, M. L. ;

Schwender, H. ;

Parker, M. M. ;

Hetmanski, J. B. ;

Balakrishnan, P. ;

Mansilla, M. A. ;

Mangold, E. ;

Ludwig, K. U. ;

Noethen, M. M. ;

Rubini, M. ;

Elcioglu, N. ;

Ruczinski, I. .

HUMAN GENETICS, 2013, 132 (07) :771-781

[7] Evidence for Gene-Environment Interaction in a Genome Wide Study of Nonsyndromic Cleft Palate [J].

Beaty, Terri H. ;

Ruczinski, Ingo ;

Murray, Jeffrey C. ;

Marazita, Mary L. ;

Munger, Ronald G. ;

Hetmanski, Jacqueline B. ;

Murray, Tanda ;

Redett, Richard J. ;

Fallin, M. Daniele ;

Liang, Kung Yee ;

Wu, Tao ;

Patel, Poorav J. ;

Jin, Sheng-Chih ;

Zhang, Tian Xiao ;

Schwender, Holger ;

Wu-Chou, Yah Huei ;

Chen, Philip K. ;

Chong, Samuel S. ;

Cheah, Felicia ;

Yeow, Vincent ;

Ye, Xiaoqian ;

Wang, Hong ;

Huang, Shangzhi ;

Jabs, Ethylin W. ;

Shi, Bing ;

Wilcox, Allen J. ;

Lie, Rolv T. ;

Jee, Sun Ha ;

Christensen, Kaare ;

Doheny, Kimberley F. ;

Pugh, Elizabeth W. ;

Ling, Hua ;

Scott, Alan F. .

GENETIC EPIDEMIOLOGY, 2011, 35 (06) :469-478

[8] A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4 [J].

Beaty, Terri H. ;

Murray, Jeffrey C. ;

Marazita, Mary L. ;

Munger, Ronald G. ;

Ruczinski, Ingo ;

Hetmanski, Jacqueline B. ;

Liang, Kung Yee ;

Wu, Tao ;

Murray, Tanda ;

Fallin, M. Daniele ;

Redett, Richard A. ;

Raymond, Gerald ;

Schwender, Holger ;

Jin, Sheng-Chih ;

Cooper, Margaret E. ;

Dunnwald, Martine ;

Mansilla, Maria A. ;

Leslie, Elizabeth ;

Bullard, Stephen ;

Lidral, Andrew C. ;

Moreno, Lina M. ;

Menezes, Renato ;

Vieira, Alexandre R. ;

Petrin, Aline ;

Wilcox, Allen J. ;

Lie, Rolv T. ;

Jabs, Ethylin W. ;

Wu-Chou, Yah Huei ;

Chen, Philip K. ;

Wang, Hong ;

Ye, Xiaoqian ;

Huang, Shangzhi ;

Yeow, Vincent ;

Chong, Samuel S. ;

Jee, Sun Ha ;

Shi, Bing ;

Christensen, Kaare ;

Melbye, Mads ;

Doheny, Kimberly F. ;

Pugh, Elizabeth W. ;

Ling, Hua ;

Castilla, Eduardo E. ;

Czeizel, Andrew E. ;

Ma, Lian ;

Field, L. Leigh ;

Brody, Lawrence ;

Pangilinan, Faith ;

Mills, James L. ;

Molloy, Anne M. ;

Kirke, Peadar N. .

NATURE GENETICS, 2010, 42 (06) :525-U76

[9] Key susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24 [J].

Birnbaum, Stefanie ;

Ludwig, Kerstin U. ;

Reutter, Heiko ;

Herms, Stefan ;

Steffens, Michael ;

Rubini, Michele ;

Baluardo, Carlotta ;

Ferrian, Melissa ;

de Assis, Nilma Almeida ;

Alblas, Margrieta A. ;

Barth, Sandra ;

Freudenberg, Jan ;

Lauster, Carola ;

Schmidt, Guel ;

Scheer, Martin ;

Braumann, Bert ;

Berge, Stefaan J. ;

Reich, Rudolf H. ;

Schiefke, Franziska ;

Hemprich, Alexander ;

Poetzsch, Simone ;

Steegers-Theunissen, Regine P. ;

Poetzsch, Bernd ;

Moebus, Susanne ;

Horsthemke, Bernhard ;

Kramer, Franz-Josef ;

Wienker, Thomas F. ;

Mossey, Peter A. ;

Propping, Peter ;

Cichon, Sven ;

Hoffmann, Per ;

Knapp, Michael ;

Noethen, Markus M. ;

Mangold, Elisabeth .

NATURE GENETICS, 2009, 41 (04) :473-477

[10] Developmental factor IRF6 exhibits tumor suppressor activity in squamous cell carcinomas [J].

Botti, Elisabetta ;

Spallone, Giulia ;

Moretti, Francesca ;

Marinari, Barbara ;

Pinetti, Valentina ;

Galanti, Sergio ;

De Meo, Paolo D'Onorio ;

De Nicola, Francesca ;

Ganci, Federica ;

Castrignano, Tiziana ;

Pesole, Graziano ;

Chimenti, Sergio ;

Guerrini, Luisa ;

Fanciulli, Maurizio ;

Blandino, Giovanni ;

Karin, Michael ;

Costanzo, Antonio .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (33) :13710-13715

← 1 2 3 4 5 6 7 8 →

共 72 条

[1] A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation [J].

Adhikari, Kaustubh ;

Fuentes-Guajardo, Macarena ;

Quinto-Sanchez, Mirsha ;

Mendoza-Revilla, Javier ;

Chacon-Duque, Juan Camilo ;

Acuna-Alonzo, Victor ;

Jaramillo, Claudia ;

Arias, William ;

Barquera Lozano, Rodrigo ;

Macin Perez, Gaston ;

Gomez-Valdes, Jorge ;

Villamil-Ramirez, Hugo ;

Hunemeier, Tabita ;

Ramallo, Virginia ;

Silva de Cerqueira, Caio C. ;

Hurtado, Malena ;

Villegas, Valeria ;

Granja, Vanessa ;

Gallo, Carla ;

Poletti, Giovanni ;

Schuler-Faccini, Lavinia ;

Salzano, Francisco M. ;

Bortolini, Maria-Catira ;

Canizales-Quinteros, Samuel ;

Cheeseman, Michael ;

Rosique, Javier ;

Bedoya, Gabriel ;

Rothhammer, Francisco ;

Headon, Denis ;

Gonzalez-Jose, Rolando ;

Balding, David ;

Ruiz-Linares, Andres .

NATURE COMMUNICATIONS, 2016, 7

[2] A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer [J].

Al-Tassan, Nada A. ;

Whiffin, Nicola ;

Hosking, Fay J. ;

Palles, Claire ;

Farrington, Susan M. ;

Dobbins, Sara E. ;

Harris, Rebecca ;

Gorman, Maggie ;

Tenesa, Albert ;

Meyer, Brian F. ;

Wakil, Salma M. ;

Kinnersley, Ben ;

Campbell, Harry ;

Martin, Lynn ;

Smith, Christopher G. ;

Idziaszczyk, Shelley ;

Barclay, Ella ;

Maughan, Timothy S. ;

Kaplan, Richard ;

Kerr, Rachel ;

Kerr, David ;

Buchannan, Daniel D. ;

Win, Aung Ko ;

Hopper, John ;

Jenkins, Mark ;

Lindor, Noralane M. ;

Newcomb, Polly A. ;

Gallinger, Steve ;

Conti, David ;

Schumacher, Fred ;

Casey, Graham ;

Dunlop, Malcolm G. ;

Tomlinson, Ian P. ;

Cheadle, Jeremy P. ;

Houlston, Richard S. .

SCIENTIFIC REPORTS, 2015, 5

[3] Nonsyndromic Cleft Lip with or without Cleft Palate in Arab Populations: Genetic Analysis of 15 Risk Loci in a Novel Case-Control Sample Recruited in Yemen [J].

Aldhorae, Khalid Ahmed ;

Boehmer, Anne C. ;

Ludwig, Kerstin U. ;

Esmail, Ahlam Hibatulla Ali ;

Al-Hebshi, Nezar Noor ;

Lippke, Baerbel ;

Goelz, Lina ;

Noethen, Markus M. ;

Daratsianos, Nikolaos ;

Knapp, Michael ;

Jaeger, Andreas ;

Mangold, Elisabeth .

BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY, 2014, 100 (04) :307-313

[4] A global reference for human genetic variation [J].

Altshuler, David M. ;

Durbin, Richard M. ;

Abecasis, Goncalo R. ;

Bentley, David R. ;

Chakravarti, Aravinda ;

Clark, Andrew G. ;

Donnelly, Peter ;

Eichler, Evan E. ;

Flicek, Paul ;

Gabriel, Stacey B. ;

Gibbs, Richard A. ;

Green, Eric D. ;

Hurles, Matthew E. ;

Knoppers, Bartha M. ;

Korbel, Jan O. ;

Lander, Eric S. ;

Lee, Charles ;

Lehrach, Hans ;

Mardis, Elaine R. ;

Marth, Gabor T. ;

McVean, Gil A. ;

Nickerson, Deborah A. ;

Wang, Jun ;

Wilson, Richard K. ;

Boerwinkle, Eric ;

Doddapaneni, Harsha ;

Han, Yi ;

Korchina, Viktoriya ;

Kovar, Christie ;

Lee, Sandra ;

Muzny, Donna ;

Reid, Jeffrey G. ;

Zhu, Yiming ;

Chang, Yuqi ;

Feng, Qiang ;

Fang, Xiaodong ;

Guo, Xiaosen ;

Jian, Min ;

Jiang, Hui ;

Jin, Xin ;

Lan, Tianming ;

Li, Guoqing ;

Li, Jingxiang ;

Li, Yingrui ;

Liu, Shengmao ;

Liu, Xiao ;

Lu, Yao ;

Ma, Xuedi ;

Tang, Meifang ;

Wang, Bo .

NATURE, 2015, 526 (7571) :68-+

[5] Fine Tuning of Craniofacial Morphology by Distant-Acting Enhancers [J].

Attanasio, Catia ;

Nord, Alex S. ;

Zhu, Yiwen ;

Blow, Matthew J. ;

Li, Zirong ;

Liberton, Denise K. ;

Morrison, Harris ;

Plajzer-Frick, Ingrid ;

Holt, Amy ;

Hosseini, Roya ;

Phouanenavong, Sengthavy ;

Akiyama, Jennifer A. ;

Shoukry, Malak ;

Afzal, Veena ;

Rubin, Edward M. ;

FitzPatrick, David R. ;

Ren, Bing ;

Hallgrimsson, Benedikt ;

Pennacchio, Len A. ;

Visel, Axel .

SCIENCE, 2013, 342 (6157)

[6] Confirming genes influencing risk to cleft lip with/without cleft palate in a case-parent trio study [J].

Beaty, T. H. ;

Taub, M. A. ;

Scott, A. F. ;

Murray, J. C. ;

Marazita, M. L. ;

Schwender, H. ;

Parker, M. M. ;

Hetmanski, J. B. ;

Balakrishnan, P. ;

Mansilla, M. A. ;

Mangold, E. ;

Ludwig, K. U. ;

Noethen, M. M. ;

Rubini, M. ;

Elcioglu, N. ;

Ruczinski, I. .

HUMAN GENETICS, 2013, 132 (07) :771-781

[7] Evidence for Gene-Environment Interaction in a Genome Wide Study of Nonsyndromic Cleft Palate [J].

Beaty, Terri H. ;

Ruczinski, Ingo ;

Murray, Jeffrey C. ;

Marazita, Mary L. ;

Munger, Ronald G. ;

Hetmanski, Jacqueline B. ;

Murray, Tanda ;

Redett, Richard J. ;

Fallin, M. Daniele ;

Liang, Kung Yee ;

Wu, Tao ;

Patel, Poorav J. ;

Jin, Sheng-Chih ;

Zhang, Tian Xiao ;

Schwender, Holger ;

Wu-Chou, Yah Huei ;

Chen, Philip K. ;

Chong, Samuel S. ;

Cheah, Felicia ;

Yeow, Vincent ;

Ye, Xiaoqian ;

Wang, Hong ;

Huang, Shangzhi ;

Jabs, Ethylin W. ;

Shi, Bing ;

Wilcox, Allen J. ;

Lie, Rolv T. ;

Jee, Sun Ha ;

Christensen, Kaare ;

Doheny, Kimberley F. ;

Pugh, Elizabeth W. ;

Ling, Hua ;

Scott, Alan F. .

GENETIC EPIDEMIOLOGY, 2011, 35 (06) :469-478

[8] A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4 [J].

Beaty, Terri H. ;

Murray, Jeffrey C. ;

Marazita, Mary L. ;

Munger, Ronald G. ;

Ruczinski, Ingo ;

Hetmanski, Jacqueline B. ;

Liang, Kung Yee ;

Wu, Tao ;

Murray, Tanda ;

Fallin, M. Daniele ;

Redett, Richard A. ;

Raymond, Gerald ;

Schwender, Holger ;

Jin, Sheng-Chih ;

Cooper, Margaret E. ;

Dunnwald, Martine ;

Mansilla, Maria A. ;

Leslie, Elizabeth ;

Bullard, Stephen ;

Lidral, Andrew C. ;

Moreno, Lina M. ;

Menezes, Renato ;

Vieira, Alexandre R. ;

Petrin, Aline ;

Wilcox, Allen J. ;

Lie, Rolv T. ;

Jabs, Ethylin W. ;

Wu-Chou, Yah Huei ;

Chen, Philip K. ;

Wang, Hong ;

Ye, Xiaoqian ;

Huang, Shangzhi ;

Yeow, Vincent ;

Chong, Samuel S. ;

Jee, Sun Ha ;

Shi, Bing ;

Christensen, Kaare ;

Melbye, Mads ;

Doheny, Kimberly F. ;

Pugh, Elizabeth W. ;

Ling, Hua ;

Castilla, Eduardo E. ;

Czeizel, Andrew E. ;

Ma, Lian ;

Field, L. Leigh ;

Brody, Lawrence ;

Pangilinan, Faith ;

Mills, James L. ;

Molloy, Anne M. ;

Kirke, Peadar N. .

NATURE GENETICS, 2010, 42 (06) :525-U76

[9] Key susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24 [J].

Birnbaum, Stefanie ;

Ludwig, Kerstin U. ;

Reutter, Heiko ;

Herms, Stefan ;

Steffens, Michael ;

Rubini, Michele ;

Baluardo, Carlotta ;

Ferrian, Melissa ;

de Assis, Nilma Almeida ;

Alblas, Margrieta A. ;

Barth, Sandra ;

Freudenberg, Jan ;

Lauster, Carola ;

Schmidt, Guel ;

Scheer, Martin ;

Braumann, Bert ;

Berge, Stefaan J. ;

Reich, Rudolf H. ;

Schiefke, Franziska ;

Hemprich, Alexander ;

Poetzsch, Simone ;

Steegers-Theunissen, Regine P. ;

Poetzsch, Bernd ;

Moebus, Susanne ;

Horsthemke, Bernhard ;

Kramer, Franz-Josef ;

Wienker, Thomas F. ;

Mossey, Peter A. ;

Propping, Peter ;

Cichon, Sven ;

Hoffmann, Per ;

Knapp, Michael ;

Noethen, Markus M. ;

Mangold, Elisabeth .

NATURE GENETICS, 2009, 41 (04) :473-477

[10] Developmental factor IRF6 exhibits tumor suppressor activity in squamous cell carcinomas [J].

Botti, Elisabetta ;

Spallone, Giulia ;

Moretti, Francesca ;

Marinari, Barbara ;

Pinetti, Valentina ;

Galanti, Sergio ;

De Meo, Paolo D'Onorio ;

De Nicola, Francesca ;

Ganci, Federica ;

Castrignano, Tiziana ;

Pesole, Graziano ;

Chimenti, Sergio ;

Guerrini, Luisa ;

Fanciulli, Maurizio ;

Blandino, Giovanni ;

Karin, Michael ;

Costanzo, Antonio .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (33) :13710-13715

← 1 2 3 4 5 6 7 8 →