Instrumental analysis of RNA modifications

被引：34
作者：
Yoluc, Yasemin [1 ]
Ammann, Gregor [1 ]
Barraud, Pierre [2 ]
Jora, Manasses [3 ]
Limbach, Patrick A. [3 ]
Motorin, Yuri [4 ]
Marchand, Virginie [5 ]
Tisne, Carine [2 ]
Borland, Kayla [1 ]
Kellner, Stefanie [1 ,6 ]
机构：
[1] Ludwig Maximilians Univ Munchen, Dept Chem, Butenandtstr 5-13, D-81377 Munich, Germany
[2] Univ Paris, Inst Biol Physicochim, IBPC, CNRS,UMR 8261,Express Genet Microbienne, Paris, France
[3] Univ Cincinnati, Dept Chem, Cincinnati, OH USA
[4] Univ Lorraine, UMR7365 IMoPA, CNRS, Nancy, France
[5] Univ Lorraine, IBSLor, Epitranscript & RNA Sequencing Core Facil, INSERM,UM S2008,CNRS, Nancy, France
[6] Goethe Univ, Inst Pharmaceut Chem, Max von Laue Str 9, D-60438 Frankfurt, Germany
来源：
CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY | 2021年 / 56卷 / 02期
基金：
美国国家科学基金会;
关键词：
E; pitranscriptome; TANDEM MASS-SPECTROMETRY; VALINE TRANSFER-RNA; ESCHERICHIA-COLI; LIQUID-CHROMATOGRAPHY; HIGH-THROUGHPUT; NUCLEIC-ACIDS; YEAST; NUCLEOSIDES; DNA; IDENTIFICATION;
D O I：
10.1080/10409238.2021.1887807
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Organisms from all domains of life invest a substantial amount of energy for the introduction of RNA modifications into nearly all transcripts studied to date. Instrumental analysis of RNA can focus on the modified residues and reveal the function of these epitranscriptomic marks. Here, we will review recent advances and breakthroughs achieved by NMR spectroscopy, sequencing, and mass spectrometry of the epitranscriptome.
引用
收藏
页码：178 / 204
页数：27
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