Modafinil in the Treatment of Debilitating Fatigue in Primary Biliary Cirrhosis: A Clinical Experience

被引：34

作者：

Gan, S. Ian ^{[1
]}

de Jongh, Mariana ^{[1
]}

Kaplan, Marshall M. ^{[1
]}

机构：

[1] Tufts Med Ctr, Div Gastroenterol, Boston, MA 02111 USA

来源：

DIGESTIVE DISEASES AND SCIENCES | 2009年 / 54卷 / 10期

关键词：

Modafinil; Primary biliary cirrhosis; Fatigue; PBC; DOUBLE-BLIND; EXCESSIVE SLEEPINESS; URSODEOXYCHOLIC ACID; DAYTIME SOMNOLENCE; CONTROLLED-TRIAL; NARCOLEPSY; METHOTREXATE; WAKEFULNESS; COLCHICINE; DISORDER;

D O I：

10.1007/s10620-008-0613-3

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Modafinil may be a potentially effective treatment for primary biliary cirrhosis (PBC)-related fatigue. About 42 patients were given a 3-day trial of 100-200 mg modafinil. Response was defined as increased energy, decreased somnolence and sleep requirements, and improved daily function. Patients with positive responses were continued indefinitely on the medication. During the initial trial period, 31 (73%) patients had complete response and continued to take the medication. Eleven (26%) had no response. In long-term follow-up (average 17.7 months), 25 (81%) patients continued to take 100-200 mg modafinil daily. Some required an increased dosage and some took the medication as needed. Four (12%) patients stopped the medication because of side-effects or reduced efficacy; one patient (3%) stopped due to medication cost and one (3%) due to resolution of fatigue. Side-effects included insomnia, nausea, nervousness, and headaches. Modafinil appears to be a safe, effective treatment for PBC-related fatigue.

引用

页码：2242 / 2246

页数：5

共 27 条

[11] An evaluation of the abuse potential of modafinil using methylphenidate as a reference [J].

Jasinski, DR .

JOURNAL OF PSYCHOPHARMACOLOGY, 2000, 14 (01) :53-60

[12] An open study of modafinil for the treatment of daytime somnolence and fatigue in primary biliary cirrhosis [J].

Jones, D. E. J. ;

Newton, J. L. .

ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2007, 25 (04) :471-476

[13] The pathogenesis and treatment of pruritus and fatigue in patients with PBC [J].

Jones, EA ;

Bergasa, NV .

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 1999, 11 (06) :623-631

[14] A prospective trial of colchicine and methotrexate in the treatment of primary biliary cirrhosis [J].

Kaplan, MM ;

Schmid, C ;

Provenzale, D ;

Sharma, A ;

Dickstein, G ;

McKusick, A .

GASTROENTEROLOGY, 1999, 117 (05) :1173-1180

[15] Modafinil for the treatment of fatigue in primary biliary cirrhosis [J].

Kaplan, MM ;

Bonis, PAL .

ANNALS OF INTERNAL MEDICINE, 2005, 143 (07) :546-547

[16] Medical progress: Primary biliary cirrhosis [J].

Kaplan, MM ;

Gershwin, ME .

NEW ENGLAND JOURNAL OF MEDICINE, 2005, 353 (12) :1261-1273

[17] Modafinil: A review of neurochemical actions and effects on cognition [J].

Minzenberg, Michael J. ;

Carter, Cameron S. .

NEUROPSYCHOPHARMACOLOGY, 2008, 33 (07) :1477-1502

[18] Fatigue in primary biliary cirrhosis is associated with excessive daytime somnolence [J].

Newton, Julia L. ;

Gibson, G. John ;

Tomlinson, Mark ;

Wilton, Katharine ;

Jones, David .

HEPATOLOGY, 2006, 44 (01) :91-98

[19] Modafinil for daytime somnolence in Parkinson's disease: double blind, placebo controlled parallel trial [J].

Ondo, WG ;

Fayle, R ;

Atassi, F ;

Jankovic, J .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2005, 76 (12) :1636-1639

[20] Acute behavioral and physiological effects of modafinil in drug abusers [J].

Rush, CR ;

Kelly, TH ;

Hays, LR ;

Baker, RW ;

Wooten, AF .

BEHAVIOURAL PHARMACOLOGY, 2002, 13 (02) :105-115

← 1 2 3 →