9-Borabicyclo[3.3.l]nonane-induced Friedel-Crafts benzylation of arenes with benzyl fluorides

被引：15

作者：

Guo, Jing ^{[1
]}

Bamford, Karlee L. ^{[1
]}

Stephan, Douglas W. ^{[1
]}

机构：

[1] Univ Toronto, Dept Chem, 80 St George St, Toronto, ON M5S 3H6, Canada

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2019年 / 17卷 / 21期

基金：

加拿大自然科学与工程研究理事会;

关键词：

C-F ACTIVATION; BOND ACTIVATION; HYDRODEFLUORINATION; CENTERS;

D O I：

10.1039/c9ob00912d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Friedel-Crafts benzylation of arenes with benzyl fluorides using 9-borabicyclo[3.3.l]nonane (9-BBN) as a mediator has been developed. This provides a simple and cheap route to the activation of C-F bonds to synthesize 1,1-diarylmethanes in good to excellent yields (up to 98%) under mild conditions. Functional group tolerance and the mechanism are considered.

引用

页码：5258 / 5261

页数：4

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