Redox Regulation Beyond ROS: Why ROS Should Not Be Measured as Often

被引：29

作者：

Brandes, Ralf P. ^{[1
,2
]}

Rezende, Flavia ^{[1
,2
]}

Schroeder, Katrin ^{[1
,2
]}

机构：

[1] Goethe Univ, Inst Kardiovaskulare Physiol, Frankfurt, Germany

[2] German Ctr Cardiovasc Res DZHK, Partner Site Rhein Main, Frankfurt, Germany

来源：

CIRCULATION RESEARCH | 2018年 / 123卷 / 03期

关键词：

antioxidants; cardiovascular diseases; cytokines; oxygen; reactive oxygen species; OXIDATION;

D O I：

10.1161/CIRCRESAHA.118.313146

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Based on the concept of oxidative stress, reactive oxygen species (ROS) have been incriminated as the drivers behind almost every cardiovascular pathology. Redox alterations are, however, omnipresent bystanders to changes in cellular activity state. Even when ROS levels are altered, their contribution to pathology is not necessarily causal. Researchers should hesitate to engage in global ROS measurements and rather aim on identifying individual molecular targets of redox regulation.

引用

页码：326 / 328

页数：3

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