An investigation of doubt in obsessive-compulsive disorder

被引：34

作者：

Samuels, Jack ^{[1
]}

Bienvenu, O. Joseph ^{[1
]}

Krasnow, Janice ^{[1
]}

Wang, Ying ^{[1
]}

Grados, Marco A. ^{[1
]}

Cullen, Bernadette ^{[1
]}

Goes, Fernando S. ^{[1
]}

Maher, Brion ^{[2
]}

Greenberg, Benjamin D. ^{[3
]}

McLaughlin, Nicole C. ^{[3
]}

Rasmussen, Steven A. ^{[3
]}

Fyer, Abby J. ^{[4
,5
]}

Knowles, James A. ^{[6
]}

Nestadt, Paul ^{[1
]}

McCracken, James T. ^{[7
]}

Piacentini, John ^{[7
]}

Geller, Dan ^{[8
]}

Pauls, David L. ^{[9
,10
,11
]}

Stewart, S. Evelyn ^{[12
]}

Murphy, Dennis L. ^{[13
]}

Shugart, Yin-Yao ^{[14
]}

Kamath, Vidya ^{[1
]}

Bakker, Arnold ^{[1
]}

Riddle, Mark A. ^{[1
]}

Nestadt, Gerald ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, 550 N Broadway 902, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Mental Hlth, Baltimore, MD USA

[3] Butler Hosp, Dept Psychiat & Human Behav, Brown Med Sch, Providence, RI 02906 USA

[4] Columbia Univ, Dept Psychiat, Coll Phys & Surg, New York, NY USA

[5] New York State Psychiat Inst & Hosp, New York, NY 10032 USA

[6] Univ Southern Calif, Dept Psychiat, Sch Med, Los Angeles, CA USA

[7] Univ Calif Los Angeles, Sch Med, Dept Psychiat & Behav Sci, Los Angeles, CA 90024 USA

[8] Harvard Med Sch, Dept Psychiat, Boston, MA USA

[9] Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA

[10] Massachusetts Gen Hosp, Psychiat & Neurodev Genet Unit, Boston, MA 02114 USA

[11] Harvard Med Sch, Boston, MA USA

[12] Univ British Columbia, Fac Med, Dept Psychiat, Vancouver, BC, Canada

[13] NIMH, Clin Sci Lab, NIH, Bldg 10, Bethesda, MD 20892 USA

[14] NIMH, Unit Stat Genom, Div Intramural Res, Bethesda, MD 20892 USA

来源：

COMPREHENSIVE PSYCHIATRY | 2017年 / 75卷

基金：

美国国家卫生研究院;

关键词：

OCD COLLABORATIVE GENETICS; DECISION-MAKING; UNCERTAINTY; CONFIDENCE; INTOLERANCE; ANXIETY; MEMORY; RELIABILITY; DIMENSIONS; PERCEPTION;

D O I：

10.1016/j.comppsych.2017.03.004

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Background: Clinicians have long considered doubt to be a fundamental characteristic of obsessive compulsive disorder (OCD). However, the clinical relevance of doubt in OCD has not been addressed. Methods: Participants included 1182 adults with OCD who had participated in family and genetic studies of OCD. We used a clinical measure of the severity of doubt, categorized as none, mild, moderate, severe, or extreme. We evaluated the relationship between doubt and OCD clinical features, Axis I disorders, personality and personality disorder dimensions, impairment, and treatment response. Results: The severity of doubt was inversely related to the age at onset of OCD symptoms. Doubt was strongly related to the number of checking symptoms and, to a lesser extent, to the numbers of contamination/cleaning and hoarding symptoms. Doubt also was related to the lifetime prevalence of recurrent major depression and generalized anxiety disorder; to the numbers of avoidant, dependent, and obsessive compulsive personality disorder traits; and to neuroticism and introversion. Moreover, doubt was strongly associated with global impairment and poor response to cognitive behavioral treatment (CBT), even adjusting for OCD severity and other correlates of doubt. Conclusions: Doubt is associated with important clinical features of OCD, including impairment and cognitive behavioral treatment response. (C) 2017 Elsevier Inc. All rights reserved.

引用

页码：117 / 124

页数：8

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