In vivo cytogenetic studies on blends of aspartame and acesulfame-K

被引：30

作者：

Mukhopadhyay, M

Mukherjee, A

Chakrabarti, J

机构：

[1] Univ Calcutta, Dept Bot, Ctr Adv Studies Cell & Chromosome Res, Calcutta 700019, W Bengal, India

[2] Cent Food Lab, Calcutta 700016, W Bengal, India

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2000年 / 38卷 / 01期

关键词：

sweetening agent; clastogenic; chromosome aberration; blends of aspartame and acesulfame-K;

D O I：

10.1016/S0278-6915(99)00115-5

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Aspartame and acesulfame-K, non-nutritive sweeteners, are permitted individually in diets and beverages. These sweeteners of different classes, used in combination, have been found to possess a synergistic sweetening effect. Whether they also have a synergistic genotoxic effect is unknown. Sn iss Albino male mire were exposed to blends of aspartame (3.5, 35, 350 mg/kg body weight) and acesulfame-K (1.5, 15 and 150 mg/kg body weight) by gavage, Bone marrow cells isolated from femora were analysed for chromosome aberrations. Statistical analysis of the results show that aspartame in combination with acesulfame-K is not significantly genotoxic, (C) 2000 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：75 / 77

页数：3

共 14 条

[1]

[Anonymous], 1981, Statistical Tables

[2]

BAEDER C, 1977, 770591 NMRI HOECHST

[3]

*FAO WHO, 1980, TECHN REP SER FAOWHO

[4]

*FAO WHO, 1993, TECHN REP SER FAOWHO, V316

[5]

MARQUARDT HWJ, 1978, MUTAGENICITY ONCOGEN

[6]

MAYER D, 1978, 780575 HOECHST AG

[7] In vivo cytogenetic studies on mice exposed to acesulfame-K -: a non-nutritive sweetener [J].

Mukherjee, A ;

Chakrabarti, J .

FOOD AND CHEMICAL TOXICOLOGY, 1997, 35 (12) :1177-1179

[8]

PRESTON RJ, 1987, MUTAT RES, V189, P157

[9]

RAIS N, 1986, SEM ART SWEETN HELD

[10]

SHENOLIKAR IS, 1986, SEM ART SWEETN HELD

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