Enantioselective Intermolecular Heck and Reductive Heck Reactions of Aryl Triflates, Mesylates, and Tosylates Catalyzed by Nickel

被引：40

作者：

Huang, Xiaolei ^{[1
]}

Teng, Shenghan ^{[1
]}

Chi, Yonggui Robin ^{[1
]}

Xu, Wenqiang ^{[2
]}

Pu, Maoping ^{[3
]}

Wu, Yun-Dong ^{[2
]}

Zhou, Jianrong Steve ^{[4
]}

机构：

[1] Peking Univ, Sch Chem Biol & Biotechnol, State Key Lab Chem Oncogen, Key Lab Chem Genom,Shenzhen Grad Sch, 2199 Lishui Rd,Room F312, Shenzhen 518055, Peoples R China

[2] Peking Univ, Lab Computat Chem & Drug Design, State Key Lab Chem Oncogen, Shenzhen Grad Sch, Shenzhen, Peoples R China

[3] Shenzhen Bay Lab, Shenzhen 518055, Peoples R China

[4] Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, 21 Nanyang Link, Singapore 637371, Singapore

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2021年 / 60卷 / 06期

关键词：

aryl halides; aryl sulfonates; Heck reaction; nickel catalysis; reductive Heck reaction; ASYMMETRIC HECK; CONJUGATE ADDITION; OXIDATIVE ADDITION; COMPLEXES; ALKENES; OLEFINS; ELECTROPHILES; ALKENYLATION; CYCLIZATIONS; ACTIVATION;

D O I：

10.1002/anie.202011036

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Nickel-catalyzed intermolecular Heck reaction of cycloalkenes proceeds well with aryl triflates, mesylates and tosylates in excellent enantiomeric ratios. The asymmetric reductive Heck reaction also works with a 2-cyclopentenone ketal, which is equivalent to conjugate arylation of the enone itself.

引用

页码：2828 / 2832

页数：5

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