Paying a Price Twice: Dose-Dependent Effects of Treg Cell-Derived TGF-β on Tolerance

被引：6

作者：

Brown, Hailey ^{[1
]}

Esterhazy, Daria ^{[1
,2
]}

机构：

[1] Univ Chicago, Comm Immunol, Chicago, IL 60637 USA

[2] Univ Chicago, Dept Pathol, 5841 S Maryland Ave, Chicago, IL 60637 USA

来源：

IMMUNITY | 2020年 / 53卷 / 06期

关键词：

D O I：

10.1016/j.immuni.2020.11.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Although many immune cells can secrete TGF-beta, whether all sources of TGF-beta are functionally equivalent is unknown. In this issue, Turner et al. uncover the importance of T regulatory (Treg) cell-intrinsic Tgfb1 gene dose in the prevention of autoimmunity and allergic disease.

引用

页码：1128 / 1130

页数：4

共 10 条

[1] Microbiota therapy acts via a regulatory T cell MyD88/RORγt pathway to suppress food allergy [J].

Abdel-Gadir, Azza ;

Stephen-Victor, Emmanuel ;

Gerber, Georg K. ;

Noval Rivas, Magali ;

Wang, Sen ;

Harb, Hani ;

Wang, Leighanne ;

Li, Ning ;

Crestani, Elena ;

Spielman, Sara ;

Secor, William ;

Biehl, Heather ;

Dibendetto, Nicholas ;

Dong, Xiaoxi ;

Umetsu, Dale T. ;

Bry, Lynn ;

Rachid, Rima ;

Chatila, Talal A. .

NATURE MEDICINE, 2019, 25 (07) :1164-+

[2] Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells [J].

Bettelli, E ;

Carrier, YJ ;

Gao, WD ;

Korn, T ;

Strom, TB ;

Oukka, M ;

Weiner, HL ;

Kuchroo, VK .

NATURE, 2006, 441 (7090) :235-238

[3] TGFβ Receptor Mutations Impose a Strong Predisposition for Human Allergic Disease [J].

Frischmeyer-Guerrerio, Pamela A. ;

Guerrerio, Anthony L. ;

Oswald, Gretchen ;

Chichester, Kristin ;

Myers, Loretha ;

Halushka, Marc K. ;

Oliva-Hemker, Maria ;

Wood, Robert A. ;

Dietz, Harry C. .

SCIENCE TRANSLATIONAL MEDICINE, 2013, 5 (195)

[4] TGF-β1 inhibits mast cell FcεRI expression [J].

Gomez, G ;

Ramirez, CD ;

Rivera, J ;

Patel, M ;

Norozian, F ;

Wright, HV ;

Kashyap, MV ;

Barnstein, BO ;

Fischer-Stenger, K ;

Schwartz, LB ;

Kepley, CL ;

Ryan, JJ .

JOURNAL OF IMMUNOLOGY, 2005, 174 (10) :5987-5993

[5] Autocrine Transforming Growth Factor-β1 Promotes In Vivo Th17 Cell Differentiation [J].

Gutcher, Ilona ;

Donkor, Moses K. ;

Ma, Qian ;

Rudensky, Alexander Y. ;

Flavell, Richard A. ;

Li, Ming O. .

IMMUNITY, 2011, 34 (03) :396-408

[6] T cell-produced transforming growth factor-β1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation [J].

Li, Ming O. ;

Wan, Yisong Y. ;

Flavell, Richard A. .

IMMUNITY, 2007, 26 (05) :579-591

[7] Oral tolerance in the absence of naturally occurring Tregs [J].

Mucida, D ;

Kutchukhidze, N ;

Erazo, A ;

Russo, M ;

Lafaille, JJ ;

de Lafaille, MAC .

JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (07) :1923-1933

[8] The microbiota regulates type 2 immunity through RORγt+ T cells [J].

Ohnmacht, Caspar ;

Park, Joo-Hong ;

Cording, Sascha ;

Wing, James B. ;

Atarashi, Koji ;

Obata, Yuuki ;

Gaboriau-Routhiau, Valerie ;

Marques, Rute ;

Dulauroy, Sophie ;

Fedoseeva, Maria ;

Busslinger, Meinrad ;

Cerf-Bensussan, Nadine ;

Boneca, Ivo G. ;

Voehringer, David ;

Hase, Koji ;

Honda, Kenya ;

Sakaguchi, Shimon ;

Eberl, Gerard .

SCIENCE, 2015, 349 (6251) :989-993

[9] TARGETED DISRUPTION OF THE MOUSE TRANSFORMING GROWTH FACTOR-BETA-1 GENE RESULTS IN MULTIFOCAL INFLAMMATORY DISEASE [J].

SHULL, MM ;

ORMSBY, I ;

KIER, AB ;

PAWLOWSKI, S ;

DIEBOLD, RJ ;

YIN, MY ;

ALLEN, R ;

SIDMAN, C ;

PROETZEL, G ;

CALVIN, D ;

ANNUNZIATA, N ;

DOETSCHMAN, T .

NATURE, 1992, 359 (6397) :693-699

[10]

Turner JA, 2020, IMMUNITY, V53, P1202, DOI [10.1016/j.immuni.2020.10.002, 10.1016/j.immuni.2020.11.011]

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