LncRNA LINC00974 Downregulates miR-122 to Upregulate RhoA in Oral Squamous Cell Carcinoma

被引：11

作者：

Tian, Yanyan ^{[1
]}

Zhong, Lin ^{[1
]}

Gao, Shanling ^{[2
]}

Yu, Yunzhi ^{[3
]}

Sun, Daocai ^{[4
]}

Liu, Xiaxia ^{[1
]}

Ji, Junying ^{[1
]}

Yao, Yanan ^{[1
]}

Liu, Yuexin ^{[1
]}

Jiang, Zhiwei ^{[1
]}

机构：

[1] Inner Mongolia Univ Sci & Technol, Affiliated Hosp Baotou Med Coll 1, Dept Stomatol, 41 Linyin Rd, Baotou 014010, Inner Mongolia, Peoples R China

[2] Baotou Eighth Hosp, Dept Stomatol, Baotou, Peoples R China

[3] Fourth Affiliated Inner Mongolia Med Univ, Hosp FIRMACO, Dept Stomatol, Baotou, Peoples R China

[4] Zhinuo Dent Clin, Baotou, Peoples R China

来源：

CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS | 2021年 / 36卷 / 01期

关键词：

LINC00974; miR-122; oral squamous cell carcinoma; prognosis; RhoA; PROLIFERATION; KNOCKDOWN; INVASION;

D O I：

10.1089/cbr.2019.2907

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: LncRNA LINC00974 participates in oral fibrogenesis, indicating its possible involvement in other oral diseases. Results: The authors found that LINC00974 was upregulated in oral squamous cell carcinoma (OSCC) and predicted poor survival. In OSCC tissues, LINC00974 was inversely correlated with miR-122 and positively correlated with RhoA. In OSCC cells, LINC00974 overexpression resulted in upregulated, whereas overexpression of miR-122 led to downregulated RhoA. Moreover, downregulated miR-122 was observed after LINC00974 overexpression, whereas LINC00974 expression was not significantly affected by miR-122 overexpression. In invasion and migration assay, miR-122 overexpression resulted in reduced, whereas LINC00974 and RhoA overexpression resulted in increased rate of cancer cell migration and invasion. In addition, miR-122 overexpression reduced the effects of LINC00974 overexpression. Conclusion: Therefore, LINC00974 can downregulate miR-122 to upregulate RhoA in OSCC, thereby promoting cell invasion and migration.

引用

页码：18 / 22

页数：5

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