Environmental enrichment improves response strength, threshold, selectivity, and latency of auditory cortex neurons

被引:146
作者
Engineer, ND [1 ]
Percaccio, CR [1 ]
Pandya, PK [1 ]
Moucha, R [1 ]
Rathbun, DL [1 ]
Kilgard, MP [1 ]
机构
[1] Univ Texas, Sch Behav & Brain Sci, Program Neurosci, Richardson, TX 75083 USA
关键词
D O I
10.1152/jn.00059.2004
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Over the last 50 yr, environmental enrichment has been shown to generate more than a dozen changes in brain anatomy. The consequences of these physical changes on information processing have not been well studied. In this study, rats were housed in enriched or standard conditions either prior to or after reaching sexual maturity. Evoked potentials from awake rats and extracellular recordings from anesthetized rats were used to document responses of auditory cortex neurons. This report details several significant, new findings about the influence of housing conditions on the responses of rat auditory cortex neurons. First, enrichment dramatically increases the strength of auditory cortex responses. Tone-evoked potentials of enriched rats, for example, were more than twice the amplitude of rats raised in standard laboratory conditions. Second, cortical responses of both young and adult animals benefit from exposure to an enriched environment and are degraded by exposure to an impoverished environment. Third, housing condition resulted in rapid remodeling of cortical responses in <2 wk. Fourth, recordings made under anesthesia indicate that enrichment increases the number of neurons activated by any sound. This finding shows that the evoked potential plasticity documented in awake rats was not due to differences in behavioral state. Finally, enrichment made primary auditory cortex (A1) neurons more sensitive to quiet sounds, more selective for tone frequency, and altered their response latencies. These experiments provide the first evidence of physiologic changes in auditory cortex processing resulting from generalized environmental enrichment.
引用
收藏
页码:73 / 82
页数:10
相关论文
共 57 条
[1]  
Ahissar Ehud, 1994, Current Opinion in Neurobiology, V4, P580, DOI 10.1016/0959-4388(94)90060-4
[2]   CLASSICAL-CONDITIONING INDUCES CS-SPECIFIC RECEPTIVE-FIELD PLASTICITY IN THE AUDITORY-CORTEX OF THE GUINEA-PIG [J].
BAKIN, JS ;
WEINBERGER, NM .
BRAIN RESEARCH, 1990, 536 (1-2) :271-286
[3]   Efficacy of sensory and motor interventions for children with autism [J].
Baranek, GT .
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS, 2002, 32 (05) :397-422
[4]   EFFECT OF THE RICHNESS OF THE ENVIRONMENT ON THE CAT VISUAL-CORTEX [J].
BEAULIEU, C ;
COLONNIER, M .
JOURNAL OF COMPARATIVE NEUROLOGY, 1987, 266 (04) :478-494
[5]   EFFECT OF THE RICHNESS OF THE ENVIRONMENT ON NEURONS IN CAT VISUAL-CORTEX .1. RECEPTIVE-FIELD PROPERTIES [J].
BEAULIEU, C ;
CYNADER, M .
DEVELOPMENTAL BRAIN RESEARCH, 1990, 53 (01) :71-81
[6]   ACETYLCHOLINESTERASE ACTIVITY AND WEIGHT MEASURES IN 15 BRAIN AREAS FROM 6 LINES OF RATS [J].
BENNETT, EL ;
DIAMOND, MC ;
MORIMOTO, H ;
HEBERT, M .
JOURNAL OF NEUROCHEMISTRY, 1966, 13 (07) :563-&
[7]   Enriched rehabilitative training promotes improved forelimb motor function and enhanced dendritic growth after focal ischemic injury [J].
Biernaskie, J ;
Corbett, D .
JOURNAL OF NEUROSCIENCE, 2001, 21 (14) :5272-5280
[8]   PERSISTENCE OF VISUAL-CORTEX DENDRITIC ALTERATIONS INDUCED BY POSTWEANING EXPOSURE TO A SUPER-ENRICHED ENVIRONMENT IN RATS [J].
CAMEL, JE ;
WITHERS, GS ;
GREENOUGH, WT .
BEHAVIORAL NEUROSCIENCE, 1986, 100 (06) :810-813
[9]   Environmental enrichment alters organizational features of the forepaw representation in the primary somatosensory cortex of adult rats [J].
Coq, JO ;
Xerri, C .
EXPERIMENTAL BRAIN RESEARCH, 1998, 121 (02) :191-204
[10]   EFFECTS OF ENVIRONMENTAL ENRICHMENT AND IMPOVERISHMENT ON RAT CEREBRAL-CORTEX [J].
DIAMOND, MC ;
LINDNER, B ;
LYON, L ;
BENNETT, EL ;
ROSENZWEIG, MR .
JOURNAL OF NEUROBIOLOGY, 1972, 3 (01) :47-+