Conservation and Enhanced Binding of SARS-CoV-2 Omicron Spike Protein to Coreceptor Neuropilin-1 Predicted by Docking Analysis

被引：21

作者：

Baindara, Piyush ^{[1
,2
,3
]}

Roy, Dinata ^{[4
]}

Mandal, Santi M. ^{[5
]}

Schrum, Adam G. ^{[1
,2
,3
]}

机构：

[1] Univ Missouri, Sch Med, Coll Engn, Dept Mol Microbiol & Immunol, Columbia, MO 65211 USA

[2] Univ Missouri, Sch Med, Coll Engn, Dept Surg, Columbia, MO 65211 USA

[3] Univ Missouri, Sch Med, Coll Engn, Dept Biomed Biol & Chem Engn, Columbia, MO 65211 USA

[4] Mizoram Univ, Dept Zool, Aizawl 796004, Mizoram, India

[5] Indian Inst Technol Kharagpur, Cent Res Facil, Kharagpur 721302, W Bengal, India

来源：

INFECTIOUS DISEASE REPORTS | 2022年 / 14卷 / 02期

关键词：

SARS-CoV-2; Omicron; spike protein; neuropilin-1; CendR; COVID-19; CELL;

D O I：

10.3390/idr14020029

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The Omicron variant of SARS-CoV-2 bears peptide sequence alterations that correlate with a higher infectivity than was observed in the original SARS-CoV-2 isolated from Wuhan, China. We analyzed the CendR motif of spike protein and performed in silico molecular docking with neuropilin-1 (Nrp1), a receptor-ligand interaction known to support infection by the original variant. Our analysis predicts conserved and slightly increased energetic favorability of binding for Omicron CendR:Nrp1. We propose that the viral spike:Nrp1 coreceptor pathway may contribute to the infectivity of the Omicron variant of SARS-CoV-2.

引用

页码：243 / 249

页数：7

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