Treatment of severe persistent asthma with IL-6 receptor blockade

被引：56

作者：

Esty, Brittany ^{[1
]}

Harb, Hani ^{[1
]}

Bartnikas, Lisa M. ^{[1
]}

Charbonnier, Louis M. ^{[1
]}

Massoud, Amir H. ^{[1
]}

Leon-Astudillo, Carmen ^{[2
]}

Visner, Gary ^{[2
]}

Subramaniam, Meera ^{[2
]}

Phipatanakul, Wanda ^{[1
]}

Chatila, Talal A. ^{[1
]}

机构：

[1] Harvard Med Sch, Boston Childrens Hosp, Dept Pediat, Div Immunol, Boston, MA 02115 USA

[2] Harvard Med Sch, Boston Childrens Hosp, Dept Pediat, Div Resp Dis, Boston, MA 02115 USA

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE | 2019年 / 7卷 / 05期

基金：

美国国家卫生研究院;

关键词：

REGULATORY T-CELLS; AIRWAY INFLAMMATION; ENDOTYPES;

D O I：

10.1016/j.jaip.2019.02.043

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

[No abstract available]

引用

页码：1639 / +

页数：8

共 12 条

[1]

Abdel-Gadir Azza, 2018, F1000Res, V7, P38, DOI 10.12688/f1000research.12650.1

[2] Endotypes of allergic diseases and asthma: An important step in building blocks for the future of precision medicine [J].

Agache, Ioana ;

Akdis, Cezmi A. .

ALLERGOLOGY INTERNATIONAL, 2016, 65 (03) :243-252

[3]

[Anonymous], 1958, STAT QUAL CONTR HDB, V2nd

[4] IL-17 and "TH2-high" asthma: Adding fuel to the fire? [J].

Bhakta, Nirav R. ;

Erle, David J. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2014, 134 (05) :1187-1188

[5] Therapeutic potential of anti-IL-6 therapies for granulocytic airway inflammation in asthma [J].

Chu, Derek K. ;

Al-Garawi, Amal ;

Llop-Guevara, Alba ;

Pillai, Regina A. ;

Radford, Katherine ;

Shen, Pamela ;

Walker, Tina D. ;

Goncharova, Susanna ;

Calhoun, William J. ;

Nair, Parameswaran ;

Jordana, Manel .

ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY, 2015, 11

[6] Increased frequency of dual-positive TH2/TH17 cells in bronchoalveolar lavage fluid characterizes a population of patients with severe asthma [J].

Irvin, Chaoyu ;

Zafar, Iram ;

Good, James ;

Rollins, Donald ;

Christianson, Christina ;

Gorska, Magdalena M. ;

Martin, Richard J. ;

Alam, Rafeul .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2014, 134 (05) :1175-+

[7] Asthma endotypes: A new approach to classification of disease entities within the asthma syndrome [J].

Lotvall, Jan ;

Akdis, Cezmi A. ;

Bacharier, Leonard B. ;

Bjermer, Leif ;

Casale, Thomas B. ;

Custovic, Adnan ;

Lemanske, Robert F. ;

Wardlaw, Andrew J. ;

Wenzel, Sally E. ;

Greenberger, Paul A. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2011, 127 (02) :355-360

[8] An asthma-associated IL4R variant exacerbates airway inflammation by promoting conversion of regulatory T cells to TH17-like cells [J].

Massoud, Amir Hossein ;

Charbonnier, Louis-Marie ;

Lopez, David ;

Pellegrini, Matteo ;

Phipatanakul, Wanda ;

Chatila, Talal A. .

NATURE MEDICINE, 2016, 22 (09) :1013-+

[9]

Montgomery DC, 2009, INTRO STAT QUALITY C, P182

[10] Regulatory T cells in allergic diseases [J].

Noval Rivas, Magali ;

Chatila, Talal A. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2016, 138 (03) :639-652

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