Neuronal polarity: microtubules strike back

被引：16

作者：

Baas, PW ^{[1
]}

机构：

[1] Drexel Univ, Coll Med, Dept Neurobiol & Anat, Philadelphia, PA 19129 USA

来源：

NATURE CELL BIOLOGY | 2002年 / 4卷 / 08期

关键词：

D O I：

10.1038/ncb0802-e194

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Specification of one neurite as the axon is the first milestone achieved as neuronal polarity is established. It is clear that regional changes in the cytoskeleton underlie axonal differentiation, but is one cytoskeletal element any more crucial than the others? Although early studies implicated microtubules, more recent studies have focused on the actin cytoskeleton as the potential hub for factors that influence axonal differentiation. Now, studies on a novel protein called CRMP-2 have shifted attention back to microtubules.

引用

页码：E194 / E195

页数：2

共 15 条

[1] Motor proteins regulate force interactions between microtubules and microfilaments in the axon [J].

Ahmad, FJ ;

Hughey, J ;

Wittmann, T ;

Hyman, A ;

Greaser, M ;

Baas, PW .

NATURE CELL BIOLOGY, 2000, 2 (05) :276-280

[2] THE TRANSPORT-PROPERTIES OF AXONAL MICROTUBULES ESTABLISH THEIR POLARITY ORIENTATION [J].

BAAS, PW ;

AHMAD, FJ .

JOURNAL OF CELL BIOLOGY, 1993, 120 (06) :1427-1437

[3] The role of local actin instability in axon formation [J].

Bradke, F ;

Dotti, CG .

SCIENCE, 1999, 283 (5409) :1931-1934

[4] INHIBITION OF NEURITE POLARITY BY TAU ANTISENSE OLIGONUCLEOTIDES IN PRIMARY CEREBELLAR NEURONS [J].

CACERES, A ;

KOSIK, KS .

NATURE, 1990, 343 (6257) :461-463

[5]

Challacombe JF, 1997, J NEUROSCI, V17, P3085

[6] Reorganization and movement of microtubules in axonal growth cones and developing interstitial branches [J].

Dent, EW ;

Callaway, JL ;

Szebenyi, G ;

Baas, PW ;

Kalil, K .

JOURNAL OF NEUROSCIENCE, 1999, 19 (20) :8894-8908

[7]

DiTella MC, 1996, J CELL SCI, V109, P467

[8]

DOTTI CG, 1988, J NEUROSCI, V8, P1454

[9] MICROTUBULE FORMATION AND NEURITE GROWTH IN CEREBELLAR MACRONEURONS WHICH DEVELOP INVITRO - EVIDENCE FOR THE INVOLVEMENT OF THE MICROTUBULE-ASSOCIATED PROTEINS, MAP-1A, HMW-MAP2 AND TAU [J].

FERREIRA, A ;

BUSCIGLIO, J ;

CACERES, A .

DEVELOPMENTAL BRAIN RESEARCH, 1989, 49 (02) :215-228

[10] CRMP-2 binds to tubulin heterodimers to promote microtubule assembly [J].

Fukata, Y ;

Itoh, TJ ;

Kimura, T ;

Ménager, C ;

Nishimura, T ;

Shiromizu, T ;

Watanabe, H ;

Inagaki, N ;

Iwamatsu, A ;

Hotani, H ;

Kaibuchi, K .

NATURE CELL BIOLOGY, 2002, 4 (08) :583-591

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