Polypyrrole merged zirconium-based metal-organic framework NU-1000 for detection of levodopa

被引：17

作者：

Biswas, Sudip ^{[1
]}

Chen, Yuling ^{[1
]}

Xie, Yao ^{[1
]}

Sun, Xin ^{[1
]}

Wang, Yang ^{[1
]}

机构：

[1] Yangzhou Univ, Coll Chem & Chem Engn, Yangzhou 225002, Jiangsu, Peoples R China

来源：

MICROCHIMICA ACTA | 2020年 / 187卷 / 12期

基金：

中国国家自然科学基金;

关键词：

Polypyrrole; L-Dopa; Levopada; Voltammetric sensor; Zr-pyrenic MOF; Metal organic framework; L-DOPA; SENSITIVE DETECTION; FUNCTIONALIZATION;

D O I：

10.1007/s00604-020-04622-y

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A post-synthetic integration of polypyrrole onto NU-1000 MOF (PPy@NU-1000) was done by pyrrole adsorption, followed by oxidative polymerization. The synthesized materials were characterized by XRD, SEM, BET, and FTIR. The ultra-high specific surface area with high-density catalytic sites of NU-1000 (2223 m(2) g(-1)) was combined with the electrical conductivity of PPy (2-100 S cm(-1)). PPy@NU-1000 provides superior electrocatalytic activity and charge transfer properties compared to an individual component. The PPy@NU-1000-modified GCE was applied to detect the biomolecule Levodopa (LD). The DPV oxidation peak of LD was strongest at 27210 mV vs. Ag/AgCl reference electrode. Under the optimized experimental condition, the fabricated electrochemical sensor exhibited a wide quantification range of 0.005-70 mu M with a sub-nanomolar detection limit of 0.0001 mu M (S/N 3). The described sensor exhibits high sensitivity (2.08 mu A mu M-1 cm(-2)) with reasonable stability, reproducibility, and selectivity for the detection LD in the presence of potentially interfering compounds. Furthermore, human serum analysis showed excellent recovery values within the range 99.3-101.6%. Validation of the method was performed against HPLC.Graphical abstract

引用

页数：7

共 30 条

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