Adult stem cell and mesenchymal progenitor theories of aging

被引：28
作者：
Fukada, So-ichiro [1 ]
Ma, Yuran [1 ]
Uezumi, Akiyoshi [2 ]
机构：
[1] Osaka Univ, Lab Mol & Cellular Physiol, Grad Sch Pharmaceut Sci, 1-6 Yamada Oka, Suita, Osaka 5650871, Japan
[2] Fujita Hlth Univ, Inst Comprehens Med Sci, Div Therapies Against Intractable Dis, Toyoake, Aichi, Japan
来源：
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2014年 / 2卷
关键词：
aging; mesenchymal progenitors; adult stem cells; oxidative stress; telomere; DNA damage; niche;
D O I：
10.3389/fcell.2014.00010
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Advances in medical science and technology allow people live longer lives, which results in age-related problems. Humans cannot avoid the various aged-related alterations of aging; in other words, humans cannot remain young at molecular and cellular levels. In 1956, Harman proposed the "free radical theory of aging" to explain the molecular mechanisms of aging. Telomere length, and accumulation of DNA or mitochondrial damage are also considered to be mechanisms of aging. On the other hand, stem cells are essential for maintaining tissue homeostasis by replacing parenchymal cells; therefore, the stem cell theory of aging is also used to explain the progress of aging. Importantly, the stem cell theory of aging is likely related to other theories. In addition, recent studies have started to reveal the essential roles of tissue-resident mesenchymal progenitors/stem cells/stromal cells in maintaining tissue homeostasis, and some evidence of their fundamental roles in the progression of aging has been presented. In this review, we discuss how stem cell and other theories connect to explain the progress of aging. In addition, we consider the mesenchymal progenitor theory of aging to describing the process of aging.
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页数：9
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共 87 条
[1]   A link between the accumulation of DNA damage and loss of multi-potency of human mesenchymal stromal cells [J].
Alves, Hugo ;
Munoz-Najar, Ursula ;
de Wit, Jan ;
Renard, Auke J. S. ;
Hoeijmakers, Jan H. J. ;
Sedivy, John M. ;
van Blitterswijk, Clemens ;
de Boer, Jan .
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2010, 14 (12) :2729-2738
[2]   Notch Signaling Is Necessary to Maintain Quiescence in Adult Muscle Stem Cells [J].
Bjornson, Christopher R. R. ;
Cheung, Tom H. ;
Liu, Ling ;
Tripathi, Pinky V. ;
Steeper, Katherine M. ;
Rando, Thomas A. .
STEM CELLS, 2012, 30 (02) :232-242
[3]   Telomere shortening and tumor formation by mouse cells lacking telomerase RNA [J].
Blasco, MA ;
Lee, HW ;
Hande, MP ;
Samper, E ;
Lansdorp, PM ;
DePinho, RA ;
Greider, CW .
CELL, 1997, 91 (01) :25-34
[4]   Gene expression profiling of human satellite cells during muscular aging using cDNA arrays [J].
Bortoli, S ;
Rehault, V ;
Eveno, E ;
Auffray, C ;
Butler-Browne, G ;
Piétu, G .
GENE, 2003, 321 :145-154
[5]   Oxidative stress targets in pulmonary emphysema: focus on the Nrf2 pathway [J].
Boutten, A. ;
Goven, D. ;
Boczkowski, J. ;
Bonay, M. .
EXPERT OPINION ON THERAPEUTIC TARGETS, 2010, 14 (03) :329-346
[6]   Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis [J].
Brack, Andrew S. ;
Conboy, Michael J. ;
Roy, Sudeep ;
Lee, Mark ;
Kuo, Calvin J. ;
Keller, Charles ;
Rando, Thomas A. .
SCIENCE, 2007, 317 (5839) :807-810
[7]   X-CHROMOSOME-LINKED MUSCULAR-DYSTROPHY (MDX) IN THE MOUSE [J].
BULFIELD, G ;
SILLER, WG ;
WIGHT, PAL ;
MOORE, KJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (04) :1189-1192
[8]   Cellular senescence: A link between cancer and age-related degenerative disease? [J].
Campisi, Judith ;
Andersen, Julie K. ;
Kapahi, Pankaj ;
Melov, Simon .
SEMINARS IN CANCER BIOLOGY, 2011, 21 (06) :354-359
[9]   Mesenchymal stem cells as trophic mediators [J].
Caplan, Arnold I. ;
Dennis, James E. .
JOURNAL OF CELLULAR BIOCHEMISTRY, 2006, 98 (05) :1076-1084
[10]   Molecular regulation of stem cell quiescence [J].
Cheung, Tom H. ;
Rando, Thomas A. .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2013, 14 (06) :329-340
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