We define a measure of coherent activity for gene regulatory networks, a property that reflects the unity of purpose between the regulatory agents with a common target. We propose that such harmonious regulatory action is desirable under a demand for energy efficiency and may be selected for under evolutionary pressures. We consider two recent models of the cell-cycle regulatory network of the yeast, Saccharomyces cerevisiae as a case study and calculate their degree of coherence. A comparison with random networks of similar size and composition reveals that the yeast's cell-cycle regulation is wired to yield an exceptionally high level of coherent regulatory activity. We also investigate the mean degree of coherence as a function of the network size, connectivity and the fraction of repressory/activatory interactions.
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Virginia Polytech Inst & State Univ, Dept Biol Sci, Blacksburg, VA 24061 USA
Virginia Polytech Inst & State Univ, Dept Elect & Comp Engn, Blacksburg, VA 24061 USA
Virginia Polytech Inst & State Univ, Dept Mech Engn, Blacksburg, VA 24061 USAVirginia Polytech Inst & State Univ, Dept Biol Sci, Blacksburg, VA 24061 USA
Barik, Debashis
Baumann, William T.
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Virginia Polytech Inst & State Univ, Dept Elect & Comp Engn, Blacksburg, VA 24061 USAVirginia Polytech Inst & State Univ, Dept Biol Sci, Blacksburg, VA 24061 USA
Baumann, William T.
Paul, Mark R.
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Virginia Polytech Inst & State Univ, Dept Mech Engn, Blacksburg, VA 24061 USAVirginia Polytech Inst & State Univ, Dept Biol Sci, Blacksburg, VA 24061 USA
Paul, Mark R.
Novak, Bela
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Univ Oxford, Ctr Integrat Syst Biol, Dept Biochem, Oxford, EnglandVirginia Polytech Inst & State Univ, Dept Biol Sci, Blacksburg, VA 24061 USA
Novak, Bela
Tyson, John J.
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Virginia Polytech Inst & State Univ, Dept Biol Sci, Blacksburg, VA 24061 USAVirginia Polytech Inst & State Univ, Dept Biol Sci, Blacksburg, VA 24061 USA