Coherent regulation in yeast's cell-cycle network

被引:2
|
作者
Aral, Nese [1 ]
Kabakcioglu, Alkan [1 ]
机构
[1] Koc Univ, Dept Phys, TR-34450 Istanbul, Turkey
关键词
coherent gene regulation; Boolean networks; yeast cell cycle; Saccharomyces cereviseae; SACCHAROMYCES-CEREVISIAE; TRANSCRIPTION FACTORS; COMPLEX NETWORKS; GENE-EXPRESSION; BOOLEAN NETWORK; FISSION YEAST; MODEL; DYNAMICS; ROBUSTNESS; EVOLUTION;
D O I
10.1088/1478-3975/12/3/036002
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
We define a measure of coherent activity for gene regulatory networks, a property that reflects the unity of purpose between the regulatory agents with a common target. We propose that such harmonious regulatory action is desirable under a demand for energy efficiency and may be selected for under evolutionary pressures. We consider two recent models of the cell-cycle regulatory network of the yeast, Saccharomyces cerevisiae as a case study and calculate their degree of coherence. A comparison with random networks of similar size and composition reveals that the yeast's cell-cycle regulation is wired to yield an exceptionally high level of coherent regulatory activity. We also investigate the mean degree of coherence as a function of the network size, connectivity and the fraction of repressory/activatory interactions.
引用
收藏
页数:9
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