Assessment of Influences of Stenoses in Right Carotid Artery on Left Carotid Artery Using Wall Stress Marker

被引:28
作者
Bit, Arindam [1 ]
Ghagare, Dushali [1 ]
Rizvanov, Albert A. [2 ]
Chattopadhyay, Himadri [3 ]
机构
[1] Natl Inst Technol, Dept Biomed Engn, Raipur, Madhya Pradesh, India
[2] Kazan Fed Univ, Kazan, Russia
[3] Jadavpur Univ, Dept Mech Engn, Kolkata, India
关键词
PULSATILE FLOW; BIFURCATION; MODELS; RHEOLOGY;
D O I
10.1155/2017/2935195
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Purpose. Atherosclerosis is a diseased condition of blood vessel. It causes partial blockage in lumen of vessel and affects hemodynamic of localized flowing blood. Complex geometries like region of bifurcation also affects hemodynamic to a larger extent. Complexity further increases in presence of stenoses at region of bifurcation. Such morphological change in vessel largely affects parent as well as corresponding sister and daughter vessels. In this paper, complexity in hemodynamic of blood in pair of carotid arteries (left and right carotid arteries) is evaluated in presence of stenoses at basilar segment of right artery in three-dimensional domain using reconstructed tomographic images of patient. Methods. Transient information of blood flow is obtained using four-dimensional phase-contrast MRI technique. Haematocrit component of blood at diseased condition is considered using Power Law and Quemada model. Numerical techniques are used to solve pressure-coupled governing equations of flowing blood. Results. Dysfunctions of endothelial cells near the wall are characterised by evaluating shear stress markers. Wall shear stress and its gradient based and harmonic based descriptors are calculated over complete geometry during one cardiac cycle. Conclusion. Internal branch of left carotid artery and external branch of right carotid artery are found prone to secondary stenoses in presence of primary stenoses at basilar segment of right carotid artery.
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页数:13
相关论文
共 22 条
[1]  
[Anonymous], 1980, Numerical heat transfer and fluid flow
[2]   Simulation of blood flow in human aorta with emphasis on outlet boundary conditions [J].
Benim, A. C. ;
Nahavandi, A. ;
Assmann, A. ;
Schubert, D. ;
Feindt, P. ;
Suh, S. H. .
APPLIED MATHEMATICAL MODELLING, 2011, 35 (07) :3175-3188
[3]   Numerical investigations of pulsatile flow in stenosed artery [J].
Bit, Arindam ;
Chattopadhyay, Himadri .
ACTA OF BIOENGINEERING AND BIOMECHANICS, 2014, 16 (04) :33-44
[4]   BLOOD VISCOSITY - INFLUENCE OF ERYTHROCYTE DEFORMATION [J].
CHIEN, S ;
USAMI, S ;
DELLENBACK, RJ ;
GREGERSEN, MI .
SCIENCE, 1967, 157 (3790) :827-+
[5]   Experimental and numerical study of pulsatile flows through stenosis: Wall shear stress analysis [J].
Deplano, V ;
Siouffi, M .
JOURNAL OF BIOMECHANICS, 1999, 32 (10) :1081-1090
[6]   Assessment of the applicability of analytical models for blood flow prediction in reconstructive surgery [J].
Drikakis, D. ;
Milionis, C. ;
Pal, S. K. ;
Patel, S. ;
Shapiro, E. .
INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING, 2011, 27 (07) :993-999
[7]   Helical flow in carotid bifurcation as surrogate marker of exposure to disturbed shear [J].
Gallo, Diego ;
Steinman, David A. ;
Bijari, Payam B. ;
Morbiducci, Umberto .
JOURNAL OF BIOMECHANICS, 2012, 45 (14) :2398-2404
[8]   LARGE-SCALE SIMULATION OF THE HUMAN ARTERIAL TREE [J].
Grinberg, L. ;
Anor, T. ;
Madsen, J. R. ;
Yakhot, A. ;
Karniadakis, G. E. .
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2009, 36 (02) :194-205
[9]   Spatial comparison between wall shear stress measures and porcine arterial endothelial permeability [J].
Himburg, HA ;
Grzybowski, DM ;
Hazel, AL ;
LaMack, JA ;
Li, XM ;
Friedman, MH .
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2004, 286 (05) :H1916-H1922
[10]   Non-Newtonian Effect on Hemodynamic Characteristics of Blood Flow in Stented Cerebral Aneurysm [J].
Huang, Changsheng ;
Chai, Zhenhua ;
Shi, Baochang .
COMMUNICATIONS IN COMPUTATIONAL PHYSICS, 2013, 13 (03) :916-928