Epidemiology of Hematologic Malignancies in Real-World Settings: Findings From the Hemato-Oncology Latin America Observational Registry Study

被引：62

作者：

de Moraes Hungria, Vania Tietsche ^{[1
]}

Chiattone, Carlos ^{[2
]}

Pavlovsky, Miguel ^{[3
]}

Abenoza, Lina M. ^{[4
]}

Agreda, Gladys P. ^{[5
]}

Armenta, Jorge ^{[6
]}

Arrais, Celso ^{[7
]}

Avendano Flores, Oscar ^{[8
]}

Barroso, Fernando ^{[9
]}

Basquiera, Ana L. ^{[10
]}

Cao, Carmen ^{[11
]}

Cugliari, Maria S. ^{[12
]}

Enrico, Alicia ^{[13
]}

Foggliatto, Laura M. ^{[14
]}

Galvez, Kenny M. ^{[15
]}

Gomez, David ^{[16
]}

Gomez, Alvaro ^{[17
]}

de Iracema, Daniel ^{[18
]}

Farias, Danielle ^{[19
]}

Lopez, Lineth ^{[20
]}

Armando Mantilla, William ^{[21
]}

Martinez, Deborah ^{[5
]}

Jose Mela, Maria ^{[3
]}

Miguel, Carlos E. ^{[22
]}

Ovilla, Roberto ^{[23
]}

Palmer, Luis ^{[24
]}

Pavlovsky, Carolina ^{[3
]}

Ramos, Christian ^{[25
]}

Remaggi, Guillermina ^{[3
]}

Santucci, Rodrigo ^{[26
]}

Schusterschitz, Sergio ^{[27
]}

Lucia Sossa, Claudia ^{[28
]}

Tuna-Aguilar, Elena ^{[5
]}

Vela, Jorge ^{[29
]}

Santos, Telma ^{[30
]}

de la Mora, Odin ^{[25
]}

Machnicki, Gerardo ^{[31
]}

Fernandez, Mariana ^{[31
]}

Barreyro, Paula ^{[31
]}

机构：

[1] Irmandade Santa Casa Misericordia Sao Paulo, Sao Paulo, Brazil

[2] Fac Ciencias Med Santa Casa Sao Paulo, Sao Paulo, Brazil

[3] FUNDALEU, Buenos Aires, DF, Argentina

[4] Fdn Santa Fe Bogota, Bogota, Colombia

[5] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Mexico City, DF, Mexico

[6] ISSEMYM, Mexico City, DF, Mexico

[7] Hosp Sirio Libanes, Sao Paulo, Brazil

[8] Med Solut SA, Guatemala City, Guatemala

[9] Hosp Univ Walter Cantidio, Fortaleza, Ceara, Brazil

[10] Hosp Privado Ctr Med Cordoba, Cordoba, Argentina

[11] Inst Nacl Canc, Santiago, Chile

[12] Inst Oncol Angel H Roffo, Buenos Aires, DF, Argentina

[13] Hosp Italiano La Plata, Buenos Aires, DF, Argentina

[14] Hosp Clin Porto Alegre, Porto Alegre, RS, Brazil

[15] Hosp Pablo Tobon Uribe, Medellin, Colombia

[16] Hosp Univ Dr Jose E Gonzalez, Mexico City, DF, Mexico

[17] Hemato Oncologos SA, Valle, Colombia

[18] CEPHO, Santo Andre, SP, Brazil

[19] Hosp Clin Univ Fed Goias, Goiania, Go, Brazil

[20] Complejo Hosp Metropolitano Dr Annulfo Arias Madr, Panama City, Panama

[21] Fdn Cardioinfantil, Bogota, Colombia

[22] Fundacao Fac Reg Med Sao Jose do Rio Preto, Sao Jose Do Rio Preto, Brazil

[23] Hosp Angeles Lomas, Huixquilucan, Mexico

[24] Complejo Med PFA Churruca Visca, Buenos Aires, DF, Argentina

[25] Hosp Gen Mexico City, Mexico City, DF, Mexico

[26] Inst Ensino & Pesquisas Sao Lucas, Sao Paulo, Brazil

[27] Univ Fed Minas Gerais, Hosp Clin, Belo Horizonte, MG, Brazil

[28] Fdn Oftalmol Santander, Santander, Colombia

[29] Inst Mexicano Seguro Social, Ctr Med Nacl Raza, Mexico City, DF, Mexico

[30] Janssen Cilag Farmaceut, Sao Paulo, Brazil

[31] Janssen Cilag Farmaceut, Buenos Aires, DF, Argentina

来源：

JOURNAL OF GLOBAL ONCOLOGY | 2019年 / 5卷

关键词：

CHRONIC LYMPHOCYTIC-LEUKEMIA; MULTIPLE-MYELOMA; DIAGNOSIS; CLASSIFICATION; GUIDELINES; LYMPHOMA;

D O I：

10.1200/JGO.19.00025

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

PURPOSE Limited information is available on multiple myeloma (MM), chronic lymphocytic leukemia (CLL), and non-Hodgkin lymphoma (NHL) management in Latin America. The primary objective of the Hemato-Oncology Latin America (HOLA) study was to describe patient characteristics and treatment patterns of Latin American patients with MM, CLL, and NHL. METHODS This study was a multicenter, retrospective, medical chart review of patients with MM, CLL, and NHL in Latin America identified between January 1, 2006, and December 31, 2015. Included were adults with at least 1 year of follow-up (except in cases of death within 1 year of diagnosis) treated at 30 oncology hospitals (Argentina, 5; Brazil, 9; Chile, 1; Colombia, 5; Mexico, 6; Panama/Guatemala, 4). RESULTS Of 5,140 patients, 2,967 (57.7%) had NHL, 1,518 (29.5%) MM, and 655 (12.7%) CLL. Median followup was 2.2 years for MM, 3.0 years for CLL, and 2.2 years for NHL, and approximately 26% died during the study observation period. Most patients had at least one comorbidity at diagnosis. The most frequent induction regimen was thalidomide-based chemotherapy for MM and chlorambucil with or without prednisone for CLL. Most patients with NHL had diffuse large B-cell lymphoma (DLBCL; 49.1%) or follicular lymphoma (FL; 19.5%). The majority of patients with DLBCL or FL received rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone. CONCLUSION The HOLA study generated an unprecedented level of high-quality, real-world evidence on characteristics and treatment patterns of patients with hematologic malignancies. Regional disparities in patient characteristics may reflect differences in ethnoracial identity and level of access to care. These data provide needed real-world evidence to understand the disease landscape in Latin America and may be used to inform clinical and health policy decision making. J Global Oncol. (C) 2019 by American Society of Clinical Oncology

引用

页码：1 / 19

页数：19

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