Liquid-phase combinatorial synthesis of alicyclic β-lactams via Ugi four-component reaction

被引：85
作者：
Gedey, S
Van der Eycken, J
Fulöp, F
机构：
[1] Univ Szeged, Inst Pharmaceut Chem, H-6701 Szeged, Hungary
[2] State Univ Ghent, Dept Organ Chem, B-9000 Ghent, Belgium
来源：
ORGANIC LETTERS | 2002年 / 4卷 / 11期
关键词：
D O I：
10.1021/ol025986r
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[GRAPHICS] Alicyclic beta-lactams were successfully synthesized via a parallel liquid-phase Ugi four-center three-component reaction (U-4C-3CR), starting from alicyclic beta-amino acids such as cis-2-aminocyclohexanecarboxylic acid, cis-2-aminocyclopentanecarboxylic acid, 2,3-diexo-3-aminobicyclo[2.2.1]heptane-2-carboxylic acid and some of their partially unsaturated analogues. A six-membered mixture-based combinatorial library of beta-lactams was also generated.
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收藏
页码：1967 / 1969
页数：3
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