Pharmacokinetics and bioequivalence of two cyclosporine oral solution formulations in cats

被引：3

作者：

Yang, Yuxin ^{[1
]}

Kong, Jingyuan ^{[1
]}

Liu, Yu ^{[1
]}

Wu, Qinyao ^{[1
]}

Cao, Yuying ^{[1
]}

Qiu, Jicheng ^{[1
]}

Zhang, Lu ^{[1
]}

Gong, Xiaohui ^{[1
]}

Zhao, Fuhua ^{[2
]}

Cao, Xingyuan ^{[1
,3
]}

Wang, Jianzhong ^{[4
]}

机构：

[1] China Agr Univ, Coll Vet Med, Dept Vet Pharmacol & Toxicol, Beijing, Peoples R China

[2] China Inst Vet Drug Control, Beijing, Peoples R China

[3] Minist Agr & Rural Affairs Peoples Republ China, Key Lab Detect Vet Drug Residues & Illegal Addit, Beijing, Peoples R China

[4] Shanxi Agr Univ, Coll Vet Med, Shanxi Key Lab Modernizat TCVM, Jinzhong, Peoples R China

来源：

FRONTIERS IN VETERINARY SCIENCE | 2022年 / 9卷

关键词：

pharmacokinetics; bioequivalence; cyclosporine oral solution; cat; four-cycle; ATOPIC-DERMATITIS; EFFICACY;

D O I：

10.3389/fvets.2022.940472

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

The pharmacokinetic profiles and bioequivalence of two cyclosporine oral solutions were investigated in cats. Twenty-four cats were randomly allocated to two equally sized treatment groups in a randomized four-cycle, and dual-sequence cross-over design. Test and reference articles were orally administered in a single dose of 7 mg/kg Bodyweight. Serial blood samples were collected, and blood cyclosporine concentration was determined by ultra-performance liquid chromatography-mass spectrometry (UPLC-MS/MS). No significant differences were present in the major pharmacokinetic parameters (C-max, AUC(0-last),) between the two formulations. The blood profiles of cyclosporine following the administration of both formulations were similar. The findings of the study suggested that the two articles were bioequivalent for cyclosporine oral solution.

引用

页数：6

共 29 条

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