Ispaghula mucilage-gellan mucoadhesive beads of metformin HCl: Development by response surface methodology

被引：48

作者：

Nayak, Amit Kumar ^{[1
]}

Pal, Dilipkumar ^{[2
]}

Santra, Kousik ^{[1
]}

机构：

[1] Seemanta Inst Pharmaceut Sci, Dept Pharmaceut, Mayurbhanj 757086, Odisha, India

[2] Guru Ghasidas Vishwavidyalaya, Dept Pharmaceut Sci, Bilaspur 495009, CG, India

来源：

CARBOHYDRATE POLYMERS | 2014年 / 107卷

关键词：

Ispaghula husk; Mucilage; Gellan gum; Mucoadhesion; Controlled drug release; Response surface methodology; CONTROLLED-RELEASE; IN-VITRO; STATISTICAL OPTIMIZATION; GUM; DELIVERY; FORMULATION; GELATION; DESIGN; SIMVASTATIN; SYSTEM;

D O I：

10.1016/j.carbpol.2014.02.022

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Response surface methodology based on 32 factorial design was used to develop ispaghula (Plantago ovata F.) husk mucilage (IHM)-gellan gum (GG) mucoadhesive beads containing metformin HCl through Ca2+-ion cross-linked ionotropic-gelation technique for the use in oral drug delivery. GG to IHM ratio and cross-linker (CaCl2) concentration were investigated as independent variables. Drug encapsulation efficiency (DEE, %) and cumulative drug release after 10 h (R-10h, %) were analyzed as dependent variables. The optimized mucoadhesive beads (F-O) showed DEE of 94.24 +/- 4.18%, R-10h of 59.13 +/- 2.27%. These beads were also characterized by SEM and FTIR analyses. The in vitro drug release from these beads showed controlled-release (zero-order) pattern with super case-II transport mechanism over 10 h. The optimized beads showed pH-dependent swelling and good mucoadhesivity with the goat intestinal mucosa. The optimized IHM-GG mucoadhesive beads containing metformin HCI exhibited significant antidiabetic effect in alloxan-induced diabetic rats over 10 h. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：41 / 50

页数：10

共 31 条

[21] Fenugreek seed mucilage-alginate mucoadhesive beads of metformin HCl: Design, optimization and evaluation [J].

Nayak, Amit Kumar ;

Pal, Dilipkumar ;

Pradhan, Jyotiprakash ;

Hasnain, M. Saquib .

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2013, 54 :144-154

[22] Development of pH-sensitive tamarind seed polysaccharide-alginate composite beads for controlled diclofenac sodium delivery using response surface methodology [J].

Nayak, Amit Kumar ;

Pal, Dilipkumar .

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2011, 49 (04) :784-793

[23] Development, Optimization, and Anti-diabetic Activity of Gliclazide-Loaded Alginate-Methyl Cellulose Mucoadhesive Microcapsules [J].

Pal, Dilipkumar ;

Nayak, Amit Kumar .

AAPS PHARMSCITECH, 2011, 12 (04) :1431-1441

[24]

Prajapati ST., 2006, Indian J Pharm Education Res, V40, P208

[25] Development of modified release gliclazide biological macromolecules using natural biodegradable polymers [J].

Prajapati, Vipulkumar D. ;

Mashru, Krupa H. ;

Solanki, Himanshu K. ;

Jani, Girish K. .

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2013, 55 :6-14

[26] Development and Statistical Optimization of Solid Lipid Nanoparticles of Simvastatin by Using 23 Full-Factorial Design [J].

Shah, Mayank ;

Pathak, Kamla .

AAPS PHARMSCITECH, 2010, 11 (02) :489-496

[27]

Sharma VK, 2008, INDIAN J PHARM EDUC, V42, P363

[28] Plantago ovata Mucilage in the Design of Fast Disintegrating Tablets [J].

Shirsand, S. B. ;

Suresh, Sarasija ;

Para, M. S. ;

Swamy, P. V. ;

Kumar, D. Nagendra .

INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2009, 71 (01) :41-45

[29] Psyllium as therapeutic and drug delivery agent [J].

Singh, Baljit .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2007, 334 (1-2) :1-14

[30] Microwave assisted synthesis and characterization of acrylamide grafted gellan, application in drug delivery [J].

Vijan, Veena ;

Kaity, Santanu ;

Biswas, Soumen ;

Isaac, Jinu ;

Ghosh, Animesh .

CARBOHYDRATE POLYMERS, 2012, 90 (01) :496-506

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