How receptors talk to trimeric G proteins

被引：490
作者：
Bourne, HR [1 ]
机构：
[1] UNIV CALIF SAN FRANCISCO,INST CARDIOVASC RES,SAN FRANCISCO,CA 94143
来源：
CURRENT OPINION IN CELL BIOLOGY | 1997年 / 9卷 / 02期
关键词：
D O I：
10.1016/S0955-0674(97)80054-3
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Stimulated by hormones and sensory stimuli, serpentine receptors promote the release of GDP that is bound to the a subunit of trimeric G proteins and its replacement by GTP. Recent investigations have begun to define the sizes, shapes, and relative orientations of receptors and G proteins, ?he surfaces through which they interact with one another, and conformational changes in both sets of molecules that underlie receptor-catalyzed guanine-nucleotide exchange.
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收藏
页码：134 / 142
页数：9
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