25 years of HIV research! ... and what about a vaccine?

被引：6

作者：

Appay, Victor ^{[1
]}

机构：

[1] Univ Paris 06, INSERM, Hop La Pitie Salpetriere, Avenir Grp,UMR S 945, F-75013 Paris, France

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 2009年 / 39卷 / 08期

关键词：

AIDS; Diversity; T-cells; Vaccine; CD8(+) T-CELLS; IMMUNODEFICIENCY VIRUS-INFECTION; IMMUNE CONTROL; NEUTRALIZING ANTIBODIES; ANTIRETROVIRAL THERAPY; DENDRITIC CELLS; RHESUS-MONKEYS; IN-VIVO; RESPONSES; ANTIGEN;

D O I：

10.1002/eji.200939551

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Over the past quarter century, colossal progress in our understanding of HIV pathogenesis has been achieved. Yet, we have no solution to the pandemic; the search for an HIV vaccine remains among the highest public health priorities. Identifying correlates of immune protection in humans, inducing effective immunity through immunization, and overcoming virus and host diversity represent the major obstacles in vaccine development. HIV vaccine research discovery may only be at its dawn.

引用

页码：1999 / 2003

页数：5

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