Facile synthesis of 2-substituted benzo[b]furans and indoles by copper-catalyzed intramolecular cyclization of 2-alkynyl phenols and tosylanilines

被引：22
作者：
Rong, Zhouting [1 ]
Gao, Kexin [1 ]
Zhou, Lei [1 ]
Lin, Jianyuan [1 ]
Qian, Guoying [1 ]
机构：
[1] Zhejiang Wanli Univ, Coll Biol & Environm Sci, Ningbo 315100, Zhejiang, Peoples R China
来源：
RSC ADVANCES | 2019年 / 9卷 / 31期
关键词：
ONE-POT SYNTHESIS; BIOACTIVE BENZOFURAN DERIVATIVES; SUBSTITUTED BENZOFURANS; EFFICIENT; ALKALOIDS; FUNCTIONALIZATION; 2-HALOPHENOLS; RELEASE; DOMINO;
D O I：
10.1039/c9ra01260e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A catalytic amount of CuCl and Cs2CO3 was employed to synthesize a variety of 2-substituted benzo[b]furans and indoles by an intramolecular cyclization of 2-alkynyl phenols and tosylanilines. This protocol features mild conditions, high yields and broad substrate scope, which makes it a practical method for the synthesis of 2-substituted benzo[b]furans and indoles.
引用
收藏
页码：17975 / 17978
页数：4
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