The future of HIV Organ Policy Equity Act is now: the state of HIV plus to HIV plus kidney transplantation in the United States

被引：15
作者：
Boyarsky, Brian J. [1 ]
Bowring, Mary Grace [1 ]
Shaffer, Ashton A. [1 ,2 ]
Segev, Dorry L. [1 ,2 ]
Durand, Christine M. [3 ,4 ]
机构：
[1] Johns Hopkins Univ, Sch Med, Dept Surg, Baltimore, MD 21205 USA
[2] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA
[3] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA
[4] Johns Hopkins Univ, Sch Med, Sidney Kimmel Canc Ctr, Baltimore, MD USA
来源：
CURRENT OPINION IN ORGAN TRANSPLANTATION | 2019年 / 24卷 / 04期
基金：
美国国家卫生研究院;
关键词：
end-stage renal disease; HIV infection; HIV Organ Policy Equity Act; kidney transplant; solid organ transplantation; STAGE RENAL-DISEASE; HIV-1-INFECTED PATIENTS; ANTIRETROVIRAL THERAPY; HEPATITIS-B; OUTCOMES; DONORS; SURVIVAL; VIRUSES; RISK;
D O I：
10.1097/MOT.0000000000000653
中图分类号：
R3 [基础医学]; R4 [临床医学];
学科分类号：
1001 ; 1002 ; 100602 ;
摘要：
Purpose of review We report the current state of HIV+ to HIV+ kidney transplantation in the United States and remaining challenges in implementing this practice nationally. Recent findings The HIV Organ Policy Equity (HOPE) Act, which was the first step in unlocking the potential of HIV+ organ donors, mandates clinical research on HIV+ to HIV+ transplantation. As of March 2019, there have been 57 HOPE donors, including both true and false positive HOPE donors resulting in more than 120 transplants. Summary The HOPE Act, signed in 2013, reversed the federal ban on the transplantation of organs from HIV+ donors into HIV+ recipients. Ongoing national studies are exploring the safety, feasibility, and efficacy of both kidney and liver transplantation in this population. If successfully and fully implemented, HIV+ to HIV+ transplantation could attenuate the organ shortage for everyone waiting, resulting in a far-reaching public health impact.
引用
收藏
页码：434 / 440
页数：7
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