The synthesis of substituted pyridylpyrimidine fungicides using palladium-catalysed cross-coupling reactions

被引：64

作者：

Hargreaves, SL ^{[1
]}

Pilkington, BL ^{[1
]}

Russell, SE ^{[1
]}

Worthington, PA ^{[1
]}

机构：

[1] Zeneca Agrochem, Dept Chem, Jealotts Hill Res Stn, Bracknell RG42 6ET, Berks, England

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 10期

关键词：

coupling reactions; palladium catalysts; pyridines; pyrimidines; fungicides;

D O I：

10.1016/S0040-4039(00)00007-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Various substituted phenyl, pyridyl and benzyl zinc chlorides have been generated from the corresponding lithium or magnesium organometallic reagents. These have been cross-coupled with 2-(6-bromo-2-pyridyl)pyrimidines in the presence of tetrakis(triphenylphosphine)palladium(0) to produce a series of substituted pyridylpyrimidine fungicides in 32-99% yields. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1653 / 1656

页数：4

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