Taking Aim at Glycolysis with CDK8 Inhibitors

被引：4
作者：
Fisher, Robert P. [1 ]
机构：
[1] Icahn Sch Med Mt Sinai, Dept Oncol Sci, New York, NY 10029 USA
来源：
TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2018年 / 29卷 / 05期
关键词：
KINASE; TRANSCRIPTION; ACTIVATION; CANCER; CELLS;
D O I：
10.1016/j.tem.2018.02.005
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Dependence on glycolysis under aerobic conditions, a frequent metabolic derangement in cancer cells, suggests a therapeutic opportunity. Now, through chemical genetics, CDK8, a kinase associated with the Mediator transcriptional coactivator complex, has emerged as an upstream inducer of glycolysis and a possible target for anticancer drug discovery.
引用
收藏
页码：281 / 282
页数：2
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