Monitoring SAW-actuated microdroplets in view of biological applications

被引：41

作者：

Renaudin, Alan ^{[1
]}

Sozanski, Jean-Pierre ^{[2
]}

Verbeke, Bernard ^{[2
]}

Zhang, Victor ^{[2
]}

Tabourier, Pierre ^{[2
]}

Druon, Christian ^{[2
]}

机构：

[1] Univ Sherbrooke, CRN2, Sherbrooke, PQ J1K 2R1, Canada

[2] CNRS, IEMN, UMR 8520, F-59652 Villeneuve Dascq, France

来源：

SENSORS AND ACTUATORS B-CHEMICAL | 2009年 / 138卷 / 01期

关键词：

SAW actuation; SAW echo; Digital microfluidics; Droplet handling; MALDI analysis; ALIGNMENT; DROPLETS; DEVICE;

D O I：

10.1016/j.snb.2009.02.031

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Droplet localization is of primary importance in (Surface Acoustic Wave) SAW-actuated droplet manipulation for the blind-control of digital microfluidics in lab-on-chips (LOC). This issue is addressed by reconsidering hereafter the implementation of our already published SAW echo method. Two echo signals are now recorded: one for the droplet at its initial known position and one for the droplet at its new unknown position after displacement. Subtracting the delays of the 2 echoes leads to an accurate determination of the unknown position provided that the droplet characteristics remain identical for the 2 considered positions. No detailed analysis of the SAW scattering by the droplet is required with this new protocol. For implementing this echo-localization method, we propose a specific LOC architecture along with software monitoring. suitable for biological applications and devoted here to protein analysis by MALDI mass spectrometry. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：374 / 382

页数：9

共 35 条

[1]

Alzuaga S, 2003, ULTRASON, P1790

[2] Microfluidic device based on surface acoustic wave [J].

Beyssen, D. ;

Le Brizoual, L. ;

Elmazria, O. ;

Alnot, P. .

SENSORS AND ACTUATORS B-CHEMICAL, 2006, 118 (1-2) :380-385

[3]

CARON F, 2006, Patent No. 2006003292

[4]

CARON F, DISPOSITIF TYPE LAB

[5] Creating, transporting, cutting, and merging liquid droplets by electrowetting-based actuation for digital microfluidic circuits [J].

Cho, SK ;

Moon, HJ ;

Kim, CJ .

JOURNAL OF MICROELECTROMECHANICAL SYSTEMS, 2003, 12 (01) :70-80

[6] Development of novel atomization system based on SAW streaming [J].

Chono, K ;

Shimizu, N ;

Matsui, Y ;

Kondoh, J ;

Shiokawa, S .

JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS BRIEF COMMUNICATIONS & REVIEW PAPERS, 2004, 43 (5B) :2987-2991

[7]

*CONTR BIOCHIPLAB, 2001, RES GENHOMME BIOINGE

[8]

De Gennes P.G., 2005, Gouttes, bulles perles et ondes

[9] Digital microfluidics: is a true lab-on-a-chip possible? [J].

Fair, R. B. .

MICROFLUIDICS AND NANOFLUIDICS, 2007, 3 (03) :245-281

[10]

GALOPIN E, 2006, 10 INT C MICR AN SYS, P651

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