Effects of Coenzyme Q10 on Blood Biochemistry in Rats

CoenzymeQ10 (CoQ10) is used as a food supplement and as an ethical drug because of its antioxidant functions and key role in mitochondrial bioenergetics. In this study, the effects of CoQ10 on blood biochemistry and malondialdehyde (MDA) levels in rats were investigated. Ten male Wistar rats ages ranging between 7 and 8 weeks were used. All animals were kept under the same condition and were given free access to standard rat chow and tap water ad libitum. The CoQ10 treated rats received daily administrations of 10 mg/kg body weight of CoQ10 by oral gavage for 10 days. Control rat groups were treated in an identical fashion with oil. The measurement of biochemical parameters; sera glucose, triglyceride, cholesterol, total protein, albumin, ALT, ALP, BUN, creatinin, calcium, magnesium, phosphorus, iron and plasma malondialdehyde levels were analysed. In CoQ10 treated rats, decreased levels of ALP and increased levels of P in serum were found compared to levels in control rats. The other parameters analyzed in the serum were not significantly different between control and CoQ10 treated rats at dose of 10 mg/kg BW for 10 days. No major effects on the parameters investigated in this study were observed following coenzyme Q10 treatment.