Galanin receptor subtypes

被引：432
作者：
Branchek, TA
Smith, KE
Gerald, C
Walker, MW
机构：
[1] Synapt Pharmaceut Corp, Res, Paramus, NJ 07652 USA
[2] Synapt Pharmaceut Corp, Target Discovery & Assessment, Paramus, NJ 07652 USA
来源：
TRENDS IN PHARMACOLOGICAL SCIENCES | 2000年 / 21卷 / 03期
关键词：
D O I：
10.1016/S0165-6147(00)01446-2
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The neuropeptide galanin, which is widely expressed in brain and peripheral tissues, exerts a broad range of physiological effects. Pharmacological studies using peptide analogues have led to speculation about multiple galanin receptor subtypes. Since 1994, a total of three G-protein-coupled receptor (GPCR) subtypes for galanin have been cloned (GAL1, gal2 and gal3). Potent, selective antagonists are yet to be found for any of the cloned receptors. Major challenges in this field include linking the receptor clones with each of the known physiological actions of galanin and evaluating the evidence for additional galanin receptor subtypes.
引用
收藏
页码：109 / 116
页数：8
相关论文
共 100 条
  • [1] GALANIN FAILS TO ALTER BOTH ACQUISITION OF A 2 TRIAL PER DAY WATER MAZE TASK AND NEUROCHEMICAL MARKERS OF CHOLINERGIC OR SEROTONERGIC NEURONS IN ADULT-RATS
    ASPLEY, S
    FONE, KCF
    [J]. BRAIN RESEARCH, 1993, 622 (1-2) : 330 - 336
  • [2] Autoradiographic mapping of cerebral blood flow responses to cholinergic stimulation of the rat substantia innominata: modulatory effect of galanin
    Barbelivien, A
    MacKenzie, ET
    Dauphin, F
    [J]. BRAIN RESEARCH, 1998, 789 (01) : 92 - 100
  • [3] GALANIN-RECEPTOR LIGAND M40 PEPTIDE DISTINGUISHES BETWEEN PUTATIVE GALANIN-RECEPTOR SUBTYPES
    BARTFAI, T
    LANGEL, U
    BEDECS, K
    ANDELL, S
    LAND, T
    GREGERSEN, S
    AHREN, B
    GIROTTI, P
    CONSOLO, S
    CORWIN, R
    CRAWLEY, J
    XU, XJ
    WIESENFELDHALLIN, Z
    HOKFELT, T
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (23) : 11287 - 11291
  • [4] BARTFAI T, 1993, CRIT REV NEUROBIOL, V7, P229
  • [5] BIOLOGICAL-ACTIVITIES OF 2 ENDOGENOUSLY OCCURRING N-TERMINALLY EXTENDED FORMS OF GALANIN IN THE RAT SPINAL-CORD
    BEDECS, K
    LANGEL, U
    XU, XJ
    WIESENFELDHALLIN, Z
    BARTFAI, T
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1994, 259 (02) : 151 - 156
  • [6] Cloning and expression of the human galanin receptor GalR2
    Bloomquist, BT
    Beauchamp, MR
    Zhelnin, L
    Brown, SE
    Gore-Willse, AR
    Gregor, P
    Cornfield, LJ
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1998, 243 (02) : 474 - 479
  • [7] Cloning and characterization of the human galanin GALR2 receptor
    Borowsky, B
    Walker, MW
    Huang, LY
    Jones, KA
    Smith, KE
    Bard, J
    Branchek, TA
    Gerald, C
    [J]. PEPTIDES, 1998, 19 (10) : 1771 - 1781
  • [8] Burazin TCD, 1998, J NEUROCHEM, V71, P879
  • [9] CLONING, PHARMACOLOGICAL CHARACTERIZATION, AND ANATOMICAL DISTRIBUTION OF A RAT CDNA-ENCODING FOR A GALANIN RECEPTOR
    BURGEVIN, MC
    LOQUET, I
    QUARTERONET, D
    HABERTORTOLI, E
    [J]. JOURNAL OF MOLECULAR NEUROSCIENCE, 1995, 6 (01) : 33 - 41
  • [10] EFFECTS OF GALANIN ON THE OPOSSUM INTERNAL ANAL-SPHINCTER - STRUCTURE-ACTIVITY RELATIONSHIP
    CHAKDER, S
    RATTAN, S
    [J]. GASTROENTEROLOGY, 1991, 100 (03) : 711 - 718
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