Bridging barriers: a comparative look at the blood-brain barrier across organisms

被引：175

作者：

O'Brown, Natasha M. ^{[1
]}

Pfau, Sarah J. ^{[1
]}

Gu, Chenghua ^{[1
]}

机构：

[1] Harvard Med Sch, Dept Neurobiol, Boston, MA 02115 USA

来源：

GENES & DEVELOPMENT | 2018年 / 32卷 / 7-8期

基金：

美国国家卫生研究院;

关键词：

blood-brain barrier; evolution; mouse; zebrafish; CENTRAL-NERVOUS-SYSTEM; VASCULAR SMOOTH-MUSCLE; ENDOTHELIAL-CELLS; ALZHEIMERS-DISEASE; NEUROVASCULAR UNIT; EARLY MACROPHAGES; CNS ANGIOGENESIS; FINE-STRUCTURE; FETAL-BRAIN; PERICYTES;

D O I：

10.1101/gad.309823.117

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The blood-brain barrier (BBB) restricts free access of molecules between the blood and the brain and is essential for regulating the neural microenvironment. Here, we describe how the BBB was initially characterized and how the current field evaluates barrier properties. We next detail the cellular nature of the BBB and discuss both the conservation and variation of BBB function across taxa. Finally, we examine our current understanding of mouse and zebrafish model systems, as we expect that comparison of the BBB across organisms will provide insight into the human BBB under normal physiological conditions and in neurological diseases.

引用

页码：466 / 478

页数：13

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