The IL-33/ST2 axis: Role in health and disease

被引：145
作者：
De la Fuente, Marjorie [1 ,2 ]
MacDonald, Thomas T. [3 ]
Hermoso, Marcela A. [1 ]
机构：
[1] Univ Chile, Fac Med, Inst Biomed Sci, Disciplinary Program Immunol, Santiago 8380453, CL, Chile
[2] Clin Las Condes, Dept Gastroenterol, Santiago, Chile
[3] Barts & London Queen Marys Sch Med & Dent, Blizard Inst, Ctr Immunol & Infect Dis, London, England
来源：
CYTOKINE & GROWTH FACTOR REVIEWS | 2015年 / 26卷 / 06期
关键词：
IL-33; ST2; Autoimmunity; Inflammatory bowel diseases; Table of contents; INFLAMMATORY-BOWEL-DISEASE; ALLERGIC AIRWAY INFLAMMATION; ST2; GENE-PRODUCT; ALTERNATIVELY ACTIVATED MACROPHAGES; RECEPTOR ACCESSORY PROTEIN; INNATE LYMPHOID-CELLS; CHRONIC HEART-FAILURE; SOLUBLE ST2; INTERLEUKIN-1; RECEPTOR; IL-1;
D O I：
10.1016/j.cytogfr.2015.07.017
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
IL-33, an IL-1 family member, is expressed by many cell types and can regulate gene transcription. IL-33 is released upon cell necrosis and the precursor form is enzymatically processed, and then drives inflammation as a damage-associated molecular pattern. The IL-33 receptor ST2, encoded by IL1RL1, is expressed as both a membrane-anchored receptor (ST2L) activated by IL-33, and as a soluble variant (sST2) that exhibits anti-inflammatory properties. The IL-33/ST2 axis is involved in the pathogenesis of atopic and autoimmune diseases, cancer, and central nervous system disorders. Here, we review recent findings on the role of the IL-33/ST2 axis in health and disease. (C) 2015 Elsevier Ltd. All rights reserved.
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收藏
页码：615 / 623
页数：9
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