From the bench to exploration medicine: NASA life sciences translational research for human exploration and habitation missions

被引:20
作者
Alwood, Joshua S. [1 ]
Ronca, April E. [1 ,2 ]
Mains, Richard C. [3 ]
Shelhamer, Mark J. [4 ]
Smith, Jeffrey D. [1 ]
Goodwin, Thomas J. [5 ]
机构
[1] NASA, Ames Res Ctr, Space BioSci Div, Moffett Field, CA 94035 USA
[2] Wake Forest Sch Med, Winston Salem, NC USA
[3] Mains Associates, Berkeley, CA USA
[4] NASA, Human Res Program, Johnson Space Ctr, Houston, TX USA
[5] NASA, Biomed Res & Environm Sci Div, Johnson Space Ctr, Houston, TX USA
关键词
LONG-DURATION SPACEFLIGHT; SPACE-FLIGHT; HUMAN CATALASE; IN-VIVO; MICE; MICROGRAVITY; BONE; VIRULENCE; ASTRONAUTS; INCREASES;
D O I
10.1038/s41526-016-0002-8
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
NASA's Space Biology and Human Research Program entities have recently spearheaded communications both internally and externally to coordinate the agency's translational research efforts. In this paper, we strongly advocate for translational research at NASA, provide recent examples of NASA sponsored early-stage translational research, and discuss options for a path forward. Our overall objective is to help in stimulating a collaborative research across multiple disciplines and entities that, working together, will more effectively and more rapidly achieve NASA's goals for human spaceflight.
引用
收藏
页数:9
相关论文
共 79 条
[1]   Rescuing US biomedical research from its systemic flaws [J].
Alberts, Bruce ;
Kirschner, Marc W. ;
Tilghman, Shirley ;
Varmus, Harold .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (16) :5773-5777
[2]  
American Society for Gravitational and Space Research, 2014, TRANSL RES ROADM WOR
[3]  
American Society for Gravitational and Space Research, 2015, TRANSL FOC S S5
[4]   Mice in Bion-M 1 Space Mission: Training and Selection [J].
Andreev-Andrievskiy, Alexander ;
Popova, Anfisa ;
Boyle, Richard ;
Alberts, Jeffrey ;
Shenkman, Boris ;
Vinogradova, Olga ;
Dolgov, Oleg ;
Anokhin, Konstantin ;
Tsvirkun, Darya ;
Soldatov, Pavel ;
Nemirovskaya, Tatyana ;
Ilyin, Eugeniy ;
Sychev, Vladimir .
PLOS ONE, 2014, 9 (08)
[5]  
[Anonymous], 2015, ENH EFF TEAM SCI
[6]  
[Anonymous], 2016, RISK CARDIOVASCULAR
[7]   Effect of microgravity on the biomechanical properties of lumbar and caudal intervertebral discs in mice [J].
Bailey, Jeannie F. ;
Hargens, Alan R. ;
Cheng, Kevin K. ;
Lotz, Jeffrey C. .
JOURNAL OF BIOMECHANICS, 2014, 47 (12) :2983-2988
[8]   Effects of spaceflight and ground recovery on mesenteric artery and vein constrictor properties in mice [J].
Behnke, Bradley J. ;
Stabley, John N. ;
McCullough, Danielle J. ;
Davis, Robert T., III ;
Dominguez, James M., II ;
Muller-Delp, Judy M. ;
Delp, Michael D. .
FASEB JOURNAL, 2013, 27 (01) :399-409
[9]   Spaceflight-Induced Bone Loss Alters Failure Mode and Reduces Bending Strength in Murine Spinal Segments [J].
Berg-Johansen, Britta ;
Liebenberg, Ellen C. ;
Li, Alfred ;
Macias, Brandon R. ;
Hargens, Alan R. ;
Lotz, Jeffrey C. .
JOURNAL OF ORTHOPAEDIC RESEARCH, 2016, 34 (01) :48-57
[10]   Mechanical unloading of bone in microgravity reduces mesenchymal and hematopoietic stem cell-mediated tissue regeneration [J].
Blaber, E. A. ;
Dvorochkin, N. ;
Torres, M. L. ;
Yousuf, R. ;
Burns, B. P. ;
Globus, R. K. ;
Almeida, E. A. C. .
STEM CELL RESEARCH, 2014, 13 (02) :181-201