Yttrium-Catalyzed Intramolecular Hydroalkoxylation/Claisen Rearrangement Sequence: Efficient Synthesis of Medium-Sized Lactams

被引：140
作者：
Zhou, Bo [1 ,2 ]
Li, Long [1 ,2 ]
Zhu, Xin-Qi [1 ,2 ]
Yan, Juan-Zhu [1 ,2 ]
Guo, Yi-Lin [1 ,2 ]
Ye, Long-Wu [1 ,2 ,3 ]
机构：
[1] Xiamen Univ, Collaborat Innovat Ctr Chem Energy Mat, State Key Lab Phys Chem Solid Surfaces, Key Lab Chem Biol Fujian Prov, Xiamen 361005, Peoples R China
[2] Xiamen Univ, Coll Chem & Chem Engn, Xiamen 361005, Peoples R China
[3] Chinese Acad Sci, State Key Lab Organomet Chem, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2017年 / 56卷 / 14期
关键词：
cyclization; heterocycles; homogeneous catalysis; rearrangements; yttrium; RING-CLOSING METATHESIS; CLAISEN-TYPE REARRANGEMENT; C-H FUNCTIONALIZATION; ELECTROPHILIC REARRANGEMENTS; CASCADE REACTION; CHIRAL YNAMIDES; GOLD CATALYSIS; LACTONES; ALKYNES; ETHERS;
D O I：
10.1002/anie.201700596
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An efficient yttrium-catalyzed intramolecular hydroalkoxylation/Claisen rearrangement sequence has been achieved, thus enabling facile access to a diverse array of valuable medium-sized lactams. Furthermore, a mechanistic rationale for this novel cascade reaction is well supported by a variety of control experiments.
引用
收藏
页码：4015 / 4019
页数：5
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