Nonhemolytic abiogenic polymers as antimicrobial peptide mimics

被引：101
作者：
Arnt, L
Nüsslein, K
Tew, GN [1 ]
机构：
[1] Univ Massachusetts, Dept Polymer Sci & Engn, Amherst, MA 01003 USA
[2] Univ Massachusetts, Dept Microbiol, Amherst, MA 01003 USA
来源：
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY | 2004年 / 42卷 / 15期
关键词：
amphiphiles; biomimetic; polyeletrolytes; magainin; phenylene ethynylene; host defense peptides; ion channel;
D O I：
10.1002/pola.20304
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
The design of abiogenic polymeric structures, which was based on hydrocarbon backbones, was described. The nonhemolytic abiogenic polymers was found to mimic the facially amphiphilic (FA) structure and biological properties of the antimicrobial peptides. The selectivity between bacteria and RBCs in FA structures with MW polydispersity was also investigated. The selectivity of the peptides such as magainin was found to originate from the overall hydrophobic moment and charge density of the structure as well as the differences between bacterial and mammalian cell membranes.
引用
收藏
页码：3860 / 3864
页数：5
相关论文
共 40 条
[1]   Structure -: Activity relationships of oligoguanidines-influence of counterion, diamine, and average molecular weight on blocidal activities [J].
Albert, M ;
Feiertag, P ;
Hayn, G ;
Saf, R ;
Hönig, H .
BIOMACROMOLECULES, 2003, 4 (06) :1811-1817
[2]   Cationic facially amphiphilic poly(phenylene ethynylene)s studied at the air-water interface [J].
Arnt, L ;
Tew, GN .
LANGMUIR, 2003, 19 (06) :2404-2408
[3]   New poly(phenyleneethynylene)s with cationic, facially amphiphilic structures [J].
Arnt, L ;
Tew, GN .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (26) :7664-7665
[4]  
Bo ZS, 1999, ANGEW CHEM INT EDIT, V38, P2370, DOI 10.1002/(SICI)1521-3773(19990816)38:16<2370::AID-ANIE2370>3.3.CO
[5]  
2-K
[6]   Toward the synthesis of artificial proteins: The discovery of an amphiphilic helical peptoid assembly [J].
Burkoth, TS ;
Beausoleil, E ;
Kaur, S ;
Tang, DZ ;
Cohen, FE ;
Zuckermann, RN .
CHEMISTRY & BIOLOGY, 2002, 9 (05) :647-654
[7]   Optimization of the antimicrobial activity of magainin peptides by modification of charge [J].
Dathe, M ;
Nikolenko, H ;
Meyer, J ;
Beyermann, M ;
Bienert, M .
FEBS LETTERS, 2001, 501 (2-3) :146-150
[8]  
DEGRADO WF, 1988, ADV PROTEIN CHEM, V39, P51
[9]   Highly luminescent diyne (-C C-CC-) containing hybrid polyphenyleneethynylene/poly(p-phenylenevinylene) polymer:: Synthesis and characterization [J].
Egbe, DAM ;
Birckner, E ;
Klemm, E .
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 2002, 40 (15) :2670-2679
[10]   Biocidal activity of polystyrenes that are cationic by virtue of protonation [J].
Gelman, MA ;
Weisblum, B ;
Lynn, DM ;
Gellman, SH .
ORGANIC LETTERS, 2004, 6 (04) :557-560
1234