Endotoxin, toll-like receptor 4, and the afferent limb of innate immunity

被引：191

作者：

Beutler, B ^{[1
]}

机构：

[1] Univ Texas, SW Med Ctr, Howard Hughes Med Inst, Dallas, TX 75235 USA

来源：

CURRENT OPINION IN MICROBIOLOGY | 2000年 / 3卷 / 01期

关键词：

D O I：

10.1016/S1369-5274(99)00046-6

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Positional cloning work and subsequent biochemical analyses have revealed that Toll-like receptor 4 (Tlr4) transduces the lipopolysaccharide (LPS) signal, alerting the host to infection by Gram-negative bacteria. Moreover, it appears that the LPS sensing pathway is a solitary one: disruption of Tlr4 causes complete unresponsiveness to LPS. As several Tlr family members exist in vertebrates, it appears likely that the innate immune system defends the host by recognizing a small number of structurally conserved molecules that distinguish the microbial world from tissues of the host.

引用

页码：23 / 28

页数：6

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