Isolation of cytotoxic sesquiterpene lactones from the Tanacetopsis karataviensis (Kovalevsk.) Kovalevsk

被引：9
作者：
Dusmatova, Dilnoza E. [1 ]
Bobakulov, Khayrulla M. [2 ]
Mukhamatkhanova, Rimma F. [1 ]
Turgunov, Kambarali K. [2 ]
Terenteva, Ekaterina O. [3 ]
Tsay, Elena A. [3 ]
Sham'yanov, Ildar D. [1 ]
Tashkhodzhaev, Bakhodir [2 ]
Azimova, Shahnoz S. [3 ]
Abdullaev, Nasrulla D. [2 ]
机构：
[1] Acad Sci Uzbek, Dept Chem Coumarins & Terpenoids, Acad S Yu Yunusov Inst Chem Plant Subst, Tashkent, Uzbekistan
[2] Acad Sci Uzbek, Dept Phys Methods Res, Acad S Yu Yunusov Inst Chem Plant Subst, Tashkent, Uzbekistan
[3] Acad Sci Uzbek, Dept Mol Genet, Acad S Yu Yunusov Inst Chem Plant Subst, Tashkent, Uzbekistan
来源：
NATURAL PRODUCT RESEARCH | 2021年 / 35卷 / 12期
关键词：
Tanacetopsis karataviensis (Kovalevsk; ) Kovalevsk; sesquiterpene lactones; cytotoxic activity; X-ray analysis; STEREOCHEMICAL ASSIGNMENT;
D O I：
10.1080/14786419.2019.1647423
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The structures and anticancer effects of two sesquiterpene lactones, 1 R,10S,3S,4R-diepoxyguai-5S,6S,7S-11(13)-en-6,12-olide (1) and hanphyllin (2) isolated from the aerial part of Tanacetopsis karataviensis (Kovalevsk.) Kovalevsk were investigated. The compound 1 was isolated for the first time as a natural compound and its structure was investigated by HR-ESI-MS, IR and NMR techniques. The X-ray diffraction analysis was performed to accurately determine the spatial structures of 1 and 2. Furthermore, we evaluated the cytotoxic activity of 1 and 2, and the chloroform fraction which contains both of them. Cytotoxic activity revealed that the effect of the chloroform fraction is stronger in growth inhibition of HeLa (89.7%) and HEp-2 (63.0%) cancer cells than the effect of individual compounds 1 (55.9 and 36.3%), 2 (78.6 and 50.3%) and the reference cisplatin (58.0 and 46.8%) respectively. Moreover, the chloroform fraction is less toxic to the hepatocytes.
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页码：1939 / 1948
页数：10
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