Female premenopausal fracture risk is associated with Gc phenotype

被引：35

作者：

Lauridsen, AL

Vestergaard, P

Hermann, AP

Moller, HJ

Mosekilde, L

Nexo, E

机构：

[1] Aarhus Univ Hosp, Dept Clin Biochem, Aarhus Kommune Hosp, DK-8000 Aarhus C, Denmark

[2] Randers Cent Sygehus, Dept Clin Biochem, Randers, Denmark

[3] Aarhus Univ Hosp, Dept Endocrinol & Metab, AAS, DK-8000 Aarhus, Denmark

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2004年 / 19卷 / 06期

关键词：

bone fractures; bone densitometry; polymorphisms; single nucleotide polymorphism; group-specific component; vitamin D binding protein; Gc-MAF; soluble CD163;

D O I：

10.1359/JBMR.040133

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The phenotype of the vitamin D binding and macrophage activating protein, Gc, is a predictor of premenopausal bone fracture risk, possibly mediated through activation of osteoclasts. This was concluded from a study on 595 Danish perimenopausal women 45-58 years of age (30,040 person years).

引用

收藏

页码：875 / 881

页数：7

相关论文

共 26 条

[1] CROSS CALIBRATION OF QDR-2000 AND QDR-1000 DUAL-ENERGY X-RAY DENSITOMETERS FOR BONE-MINERAL AND SOFT-TISSUE MEASUREMENTS [J].

ABRAHAMSEN, B ;

GRAM, J ;

HANSEN, TB ;

BECKNIELSEN, H .

BONE, 1995, 16 (03) :385-390

[2]

BRAUN A, 1992, HUM GENET, V89, P401

[3] EFFICACY OF WHEAT-GERM LECTIN-PRECIPITATED ALKALINE-PHOSPHATASE IN SERUM AS AN ESTIMATOR OF BONE MINERALIZATION RATE - COMPARISON TO SERUM TOTAL ALKALINE-PHOSPHATASE AND SERUM BONE GLA-PROTEIN [J].

BRIXEN, K ;

NIELSEN, HK ;

ERIKSEN, EF ;

CHARLES, P ;

MOSEKILDE, L .

CALCIFIED TISSUE INTERNATIONAL, 1989, 44 (02) :93-98

[4] THE MUTANTS OF THE VITAMIN-D-BINDING PROTEIN - MORE THAN 120 VARIANTS OF THE GC/DBP SYSTEM [J].

CLEVE, H ;

CONSTANS, J .

VOX SANGUINIS, 1988, 54 (04) :215-225

[5] RISK-FACTORS FOR HIP FRACTURE IN WHITE WOMEN [J].

CUMMINGS, SR ;

NEVITT, MC ;

BROWNER, WS ;

STONE, K ;

FOX, KM ;

ENSRUD, KE ;

CAULEY, JC ;

BLACK, D ;

VOGT, TM .

NEW ENGLAND JOURNAL OF MEDICINE, 1995, 332 (12) :767-773

[6] Association of molecular variants, haplotypes, and linkage disequilibrium within the human vitamin D-binding protein (DBP) gene with postmenopausal bone mineral density [J].

Ezura, Y ;

Nakajima, T ;

Kajita, M ;

Ishida, R ;

Inoue, S ;

Yoshida, H ;

Suzuki, T ;

Shiraki, M ;

Hosoi, T ;

Orimo, H ;

Emi, M .

JOURNAL OF BONE AND MINERAL RESEARCH, 2003, 18 (09) :1642-1649

[7] ETHNIC VARIATION IN VITAMIN-D-BINDING PROTEIN (GC) - A REVIEW OF ISOELECTRIC-FOCUSING STUDIES IN HUMAN-POPULATIONS [J].

KAMBOH, MI ;

FERRELL, RE .

HUMAN GENETICS, 1986, 72 (04) :281-293

[8] Linkage of structure at the proximal femur to chromosomes 3, 7, 8, and 19 [J].

Koller, DL ;

White, KE ;

Liu, G ;

Hui, SL ;

Conneally, PM ;

Johnston, CC ;

Econs, MJ ;

Foroud, T ;

Peacock, M .

JOURNAL OF BONE AND MINERAL RESEARCH, 2003, 18 (06) :1057-1065

[9] Genome screen for quantitative trait loci underlying normal variation in femoral structure [J].

Koller, DL ;

Liu, GD ;

Econs, MJ ;

Hui, SL ;

Morin, PA ;

Joslyn, G ;

Rodriguez, LA ;

Conneally, PM ;

Christian, JC ;

Johnston, CC ;

Foroud, T ;

Peacock, M .

JOURNAL OF BONE AND MINERAL RESEARCH, 2001, 16 (06) :985-991

[10] Identification of the haemoglobin scavenger receptor [J].

Kristiansen, M ;

Graversen, JH ;

Jacobsen, C ;

Sonne, O ;

Hoffman, HJ ;

Law, SKA ;

Moestrup, SK .

NATURE, 2001, 409 (6817) :198-201