Stem Cells Matter in Response to Fasting

被引:4
作者
Sailaja, Badi Sri [1 ]
He, Xi C. [1 ]
Li, Linheng [1 ,2 ]
机构
[1] Stowers Inst Med Res, Kansas City, MO 64110 USA
[2] Univ Kansas, Med Ctr, Dept Pathol & Lab Med, Kansas City, KS 66101 USA
来源
CELL REPORTS | 2015年 / 13卷 / 11期
关键词
PTEN;
D O I
10.1016/j.celrep.2015.12.008
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The molecular processes underlying intestinal adaptation to fasting and re-feeding remain largely uncharacterized. In this issue of Cell Reports, Richmond et al. report that dormant intestinal stem cells are regulated by PTEN and nutritional status.
引用
收藏
页码:2325 / 2326
页数:2
相关论文
共 10 条
  • [1] Krt19+/Lgr5- Cells Are Radioresistant Cancer-Initiating Stem Cells in the Colon and Intestine
    Asfaha, Samuel
    Hayakawa, Yoku
    Muley, Ashlesha
    Stokes, Sarah
    Graham, Trevor A.
    Ericksen, Russell E.
    Westphalen, Christoph B.
    von Burstin, Johannes
    Mastracci, Teresa L.
    Worthley, Daniel L.
    Guha, Chandhan
    Quante, Michael
    Rustgi, Anil K.
    Wang, Timothy C.
    [J]. CELL STEM CELL, 2015, 16 (06) : 627 - 638
  • [2] BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-β-catenin signaling
    He, XC
    Zhang, JW
    Tong, WG
    Tawfik, O
    Ross, J
    Scoville, DH
    Tian, Q
    Zeng, X
    He, X
    Wiedemann, LM
    Mishina, Y
    Li, LH
    [J]. NATURE GENETICS, 2004, 36 (10) : 1117 - 1121
  • [3] PTEN-deficient intestinal stem cells initiate intestinal polyposis
    He, Xi C.
    Yin, Tong
    Grindley, Justin C.
    Tian, Qiang
    Sato, Toshiro
    Tao, W. Andy
    Dirisina, Raminarao
    Porter-Westpfahl, Kimberly S.
    Hembree, Mark
    Johnson, Teri
    Wiedemann, Leanne M.
    Barrett, Terrence A.
    Hood, Leroy
    Wu, Hong
    Li, Linheng
    [J]. NATURE GENETICS, 2007, 39 (02) : 189 - 198
  • [4] Coexistence of Quiescent and Active Adult Stem Cells in Mammals
    Li, Linheng
    Clevers, Hans
    [J]. SCIENCE, 2010, 327 (5965) : 542 - 545
  • [5] Fasting: Molecular Mechanisms and Clinical Applications
    Longo, Valter D.
    Mattson, Mark P.
    [J]. CELL METABOLISM, 2014, 19 (02) : 181 - 192
  • [6] PTEN Mutations as a Cause of Constitutive Insulin Sensitivity and Obesity
    Pal, Aparna
    Barber, Thomas M.
    Van de Bunt, Martijn
    Rudge, Simon A.
    Zhang, Qifeng
    Lachlan, Katherine L.
    Cooper, Nicola S.
    Linden, Helen
    Levy, Jonathan C.
    Wakelam, Michael J. O.
    Walker, Lisa
    Karpe, Fredrik
    Gloyn, Anna L.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2012, 367 (11) : 1002 - 1011
  • [7] Dormant Intestinal Stem Cells Are Regulated by PTEN and Nutritional Status
    Richmond, Camilla A.
    Shah, Manasvi S.
    Deary, Luke T.
    Trotier, Danny C.
    Thomas, Horatio
    Ambruzs, Dana M.
    Jiang, Lijie
    Whiles, Bristol B.
    Rickner, Hannah D.
    Montgomery, Robert K.
    Tovaglieri, Alessio
    Carlone, Diana L.
    Breault, David T.
    [J]. CELL REPORTS, 2015, 13 (11): : 2403 - 2411
  • [8] Impersonalized Medicine
    Scrable, Heidi
    [J]. SCIENCE TRANSLATIONAL MEDICINE, 2012, 4 (124)
  • [9] Interconversion Between Intestinal Stem Cell Populations in Distinct Niches
    Takeda, Norifumi
    Jain, Rajan
    LeBoeuf, Matthew R.
    Wang, Qiaohong
    Lu, Min Min
    Epstein, Jonathan A.
    [J]. SCIENCE, 2011, 334 (6061) : 1420 - 1424
  • [10] mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake
    Yilmaz, Oemer H.
    Katajisto, Pekka
    Lamming, Dudley W.
    Gueltekin, Yetis
    Bauer-Rowe, Khristian E.
    Sengupta, Shomit
    Birsoy, Kivanc
    Dursun, Abdulmetin
    Yilmaz, V. Onur
    Selig, Martin
    Nielsen, G. Petur
    Mino-Kenudson, Mari
    Zukerberg, Lawrence R.
    Bhan, Atul K.
    Deshpande, Vikram
    Sabatini, David M.
    [J]. NATURE, 2012, 486 (7404) : 490 - U87