Ivermectin, Famotidine, and Doxycycline: A Suggested Combinatorial Therapeutic for the Treatment of COVID-19

被引:17
作者
Sen Gupta, Parth Sarthi [1 ]
Rana, Malay Kumar [1 ]
机构
[1] Indian Inst Sci Educ & Res IISER Berhampur, Dept Chem Sci, Berhampur 760010, Odisha, India
关键词
COVID-19; antiviral; ivermectin; famotidine; and doxycycline; REPLICATION;
D O I
10.1021/acsptsci.0c00140
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
At times, combination therapy has proven to be very effective. While no cure is available to date, herein we put forward with rationale and supporting evidence that if administrated simultaneously, a combination of FDA-approved drugs comprising ivermectin, famotidine, and doxycycline may provide robust chemoprophylaxis effective against COVID-19.
引用
收藏
页码:1037 / 1038
页数:2
相关论文
共 10 条
[1]   The effect of histamine type 2 receptor antagonists on human immunodeficiency virus (HIV) replication: Identification of a new class of antiviral agents [J].
Bourinbaiar, AS ;
Fruhstorfer, EC .
LIFE SCIENCES, 1996, 59 (23) :PL365-PL370
[2]   The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro [J].
Caly, Leon ;
Druce, Julian D. ;
Catton, Mike G. ;
Jans, David A. ;
Wagstaff, Kylie M. .
ANTIVIRAL RESEARCH, 2020, 178
[3]   Famotidine Use Is Associated With Improved Clinical Outcomes in Hospitalized COVID-19 Patients: A Propensity Score Matched Retrospective Cohort Study [J].
Freedberg, Daniel E. ;
Conigliaro, Joseph ;
Wang, Timothy C. ;
Tracey, Kevin J. ;
Callahan, Michael V. ;
Abrams, Julian A. .
GASTROENTEROLOGY, 2020, 159 (03) :1129-+
[4]   Triple combination of interferon beta-1b, lopinavir-ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial [J].
Hung, Ivan Fan-Ngai ;
Lung, Kwok-Cheung ;
Tso, Eugene Yuk-Keung ;
Liu, Raymond ;
Chung, Tom Wai-Hin ;
Chu, Man-Yee ;
Ng, Yuk-Yung ;
Lo, Jenny ;
Chan, Jacky ;
Tam, Anthony Raymond ;
Shum, Hoi-Ping ;
Chan, Veronica ;
Wu, Alan Ka-Lun ;
Sin, Kit-Man ;
Leung, Wai-Shing ;
Law, Wai-Lam ;
Lung, David Christopher ;
Sin, Simon ;
Yeung, Pauline ;
Yip, Cyril Chik-Yan ;
Zhang, Ricky Ruiqi ;
Fung, Agnes Yim-Fong ;
Yan, Erica Yuen-Wing ;
Leung, Kit-Hang ;
Ip, Jonathan Daniel ;
Chu, Allen Wing-Ho ;
Chan, Wan-Mui ;
Ng, Anthony Chin-Ki ;
Lee, Rodney ;
Fung, Kitty ;
Yeung, Alwin ;
Wu, Tak-Chiu ;
Chan, Johnny Wai-Man ;
Yan, Wing-Wah ;
Chan, Wai-Ming ;
Chan, Jasper Fuk-Woo ;
Lie, Albert Kwok-Wai ;
Tsang, Owen Tak-Yin ;
Cheng, Vincent Chi-Chung ;
Que, Tak-Lun ;
Lau, Chak-Sing ;
Chan, Kwok-Hung ;
To, Kelvin Kai-Wang ;
Yuen, Kwok-Yung .
LANCET, 2020, 395 (10238) :1695-1704
[5]  
Kritas SK, 2020, J BIOL REG HOMEOS AG, V34, P9, DOI 10.23812/20-Editorial-Kritas
[6]  
Rajter J. C., 2020, ICON IVERMECTIN COVI, DOI [10.1101/2020.06.06.20124461, DOI 10.1101/2020.06.06.20124461]
[7]   Inhibitory effect of doxycycline against dengue virus replication in vitro [J].
Rothan, Hussin A. ;
Mohamed, Zulqarnain ;
Paydar, Mohammadjavad ;
Abd Rahman, Noorsaadah ;
Yusof, Rohana .
ARCHIVES OF VIROLOGY, 2014, 159 (04) :711-718
[8]  
Sen Gupta P. S., 2020, BINDING MECH STRUCTU, DOI [10.26434/chem-rxiv.12463946.v1, DOI 10.26434/CHEM-RXIV.12463946.V1]
[9]   Binding insight of clinically oriented drug famotidine with the identified potential target of SARS-CoV-2 [J].
Sen Gupta, Parth Sarthi ;
Biswal, Satyaranjan ;
Singha, Dipankar ;
Rana, Malay Kumar .
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2021, 39 (14) :5327-5333
[10]   Ivermectin is a specific inhibitor of importin α/β-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus [J].
Wagstaff, Kylie M. ;
Sivakumaran, Haran ;
Heaton, Steven M. ;
Harrich, David ;
Jans, David A. .
BIOCHEMICAL JOURNAL, 2012, 443 :851-856