Two bioactive compounds from the Chinese scorpion Buthus martensii Karsch

被引：13
作者：
Gao, Jiayu [1 ]
Yin, Weiping [1 ]
Gao, Ting [1 ]
Deng, Ruixue [1 ]
Li, Xin [1 ]
机构：
[1] Henan Univ Sci & Technol, Sch Chem Engn & Pharmaceut, Luoyang 471023, Henan, Peoples R China
来源：
NATURAL PRODUCT RESEARCH | 2014年 / 28卷 / 10期
基金：
中国国家自然科学基金;
关键词：
toxic digitalis aglucon; Buthus martensii Karsch; insect nature products; antibacterial activity; cardenolides; scorpion; STEROIDAL SAPONINS; CARDENOLIDES; GLYCOSIDES; SPECTRA;
D O I：
10.1080/14786419.2013.873433
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Two compounds, 3 beta-acetoxyl,2,14,22-trihydroxy,19-hydroxymethyl,9 alpha,5 beta,14 beta-card-20(22)enolide (1) and 1,2,3,4-tetrahydro-6-hydroxy1-5-pyrimidinecarbox-aldehyde (2), were isolated from arthropods in scorpion, Buthus martensii Karsch, by medium pressure liquid chromatography with silica gel as stationary phase and RP-HPLC analysis technology. The structures were elucidated on the basis of NMR spectroscopic analysis and HR-ESI-MS determination. It was found that (1) is a novel compound and both compounds showed inhibitory activities against the Gram-positive bacteria Bacillus subtilis (minimum inhibitory concentrations=15 mu g/mL), with diameter of inhibition zone at phi=6.0mm (compound 1) and phi=9.0mm (compound 2), respectively.
引用
收藏
页码：698 / 703
页数：6
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