Parkinsonism, small vessel disease, and white matter disease Is there a link?

被引：2

作者：

Luca, Corneliu C. ^{[1
]}

Rundek, Tatjana ^{[1
]}

机构：

[1] Univ Miami, Dept Neurol, Miller Sch Med, Coral Gables, FL 33124 USA

来源：

NEUROLOGY | 2015年 / 85卷 / 18期

关键词：

VASCULAR PARKINSONISM; LESIONS;

D O I：

10.1212/WNL.0000000000002091

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Parkinsonian syndrome is primarily attributed to striato-nigral degeneration as idiopathic Parkinson disease (PD), although it can be caused by white matter (WM) disease as classically seen in vascular parkinsonism (VP). VP clinically manifests as predominant lower extremities involvement and gait impairment with poor response to levodopa and, radiologically, as WM hyperintensities (WMH) that disrupt the striato-nigral pathways. However, brain MRI vascular lesions correlate poorly with clinical manifestations and pathology findings.(1)

引用

页码：1532 / 1533

页数：2

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